Mechanisms of systems memory consolidation during sleep

JG Klinzing, N Niethard, J Born - Nature neuroscience, 2019 - nature.com
Long-term memory formation is a major function of sleep. Based on evidence from
neurophysiological and behavioral studies mainly in humans and rodents, we consider the …

Sleep spindles: mechanisms and functions

LMJ Fernandez, A Lüthi - Physiological reviews, 2020 - journals.physiology.org
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping
mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As …

[HTML][HTML] Norepinephrine links astrocytic activity to regulation of cortical state

ME Reitman, V Tse, X Mi, DD Willoughby… - Nature …, 2023 - nature.com
Cortical state, defined by population-level neuronal activity patterns, determines sensory
perception. While arousal-associated neuromodulators—including norepinephrine (NE) …

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

NE Fultz, G Bonmassar, K Setsompop, RA Stickgold… - Science, 2019 - science.org
Sleep is essential for both cognition and maintenance of healthy brain function. Slow waves
in neural activity contribute to memory consolidation, whereas cerebrospinal fluid (CSF) …

Human REM sleep recalibrates neural activity in support of memory formation

JD Lendner, N Niethard, BA Mander… - Science …, 2023 - science.org
The proposed mechanisms of sleep-dependent memory consolidation involve the overnight
regulation of neural activity at both synaptic and whole-network levels. Now, there is a lack …

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

GH Diering, RS Nirujogi, RH Roth, PF Worley… - Science, 2017 - science.org
Sleep is an essential process that supports learning and memory by acting on synapses
through poorly understood molecular mechanisms. Using biochemistry, proteomics, and …

[HTML][HTML] Microglia regulate sleep through calcium-dependent modulation of norepinephrine transmission

C Ma, B Li, D Silverman, X Ding, A Li, C Xiao… - Nature …, 2024 - nature.com
Sleep interacts reciprocally with immune system activity, but its specific relationship with
microglia—the resident immune cells in the brain—remains poorly understood. Here, we …

Oscillating circuitries in the sleeping brain

AR Adamantidis, C Gutierrez Herrera… - Nature Reviews …, 2019 - nature.com
Brain activity during sleep is characterized by circuit-specific oscillations, including slow
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …

[HTML][HTML] Gamma oscillations as a biomarker for major depression: an emerging topic

PJ Fitzgerald, BO Watson - Translational psychiatry, 2018 - nature.com
Identifying biomarkers for major depression is of high importance for improving diagnosis
and treatment of this common and debilitating neuropsychiatric disorder, as the field seeks …

[HTML][HTML] An electrophysiological marker of arousal level in humans

JD Lendner, RF Helfrich, BA Mander, L Romundstad… - elife, 2020 - elifesciences.org
Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are
prominent states of reduced arousal linked to the occurrence of synchronized oscillations in …