[HTML][HTML] Beyond the Anticodon: tRNA Core Modifications and Their Impact on Structure, Translation and Stress Adaptation
MJ Yared, A Marcelot, P Barraud - Genes, 2024 - mdpi.com
Transfer RNAs (tRNAs) are heavily decorated with post-transcriptional chemical
modifications. Approximately 100 different modifications have been identified in tRNAs, and …
modifications. Approximately 100 different modifications have been identified in tRNAs, and …
[HTML][HTML] RNA modifying enzymes shape tRNA biogenesis and function
SK Schultz, U Kothe - Journal of Biological Chemistry, 2024 - Elsevier
Transfer RNAs (tRNAs) are the most highly modified cellular RNAs, both with respect to the
proportion of nucleotides that are modified within the tRNA sequence and with respect to the …
proportion of nucleotides that are modified within the tRNA sequence and with respect to the …
Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs
K Zhang, A Manning, JM Lentini, J Howard, F Dalwigk… - bioRxiv, 2024 - biorxiv.org
The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes m2, 2G modification in tRNAs.
Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) …
Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) …
TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress.
SP Hwang, H Liao, K Barondeau, X Han, C Herbert… - bioRxiv, 2024 - biorxiv.org
Mapping of the epitranscriptome has revealed the chemical diversity of RNA modifications
and their functional importance in regulating gene expression. Transfer RNAs (tRNAs) are …
and their functional importance in regulating gene expression. Transfer RNAs (tRNAs) are …