Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

[HTML][HTML] Oxidative stress: Normal pregnancy versus preeclampsia

DI Chiarello, C Abad, D Rojas, F Toledo… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The role of oxidative stress in the physiopathology of human pregnancy is of particular
interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a …

The placenta: a maternofetal interface

K O'Brien, Y Wang - Annual Review of Nutrition, 2023 - annualreviews.org
The placenta is the gatekeeper between the mother and the fetus. Over the first trimester of
pregnancy, the fetus is nourished by uterine gland secretions in a process known as …

Something old, something new: digital quantification of uterine vascular remodelling and trophoblast plugging in historical collections provides new insight into …

HH Allerkamp, AR Clark, TC Lee… - Human …, 2021 - academic.oup.com
STUDY QUESTION What is the physiological extent of vascular remodelling in and
trophoblast plugging of the uterine circulation across the first half of pregnancy? SUMMARY …

The complement system and preeclampsia

JF Regal, RM Burwick, SD Fleming - Current hypertension reports, 2017 - Springer
Abstract Purpose of Review Preeclampsia affects 3–4% of pregnancies with few treatment
options to reduce maternal and fetal harm. Recent evidence that targeting the complement …

Trophoblast plugs: impact on utero-placental haemodynamics and spiral artery remodelling

JL James, R Saghian, R Perwick… - Human …, 2018 - academic.oup.com
STUDY QUESTION How does trophoblast plugging impact utero-placental
haemodynamics? SUMMARY ANSWER Physiological trophoblast plug structures are dense …

[HTML][HTML] Preeclampsia is a syndrome with a cascade of pathophysiologic events

W Gyselaers - Journal of clinical medicine, 2020 - mdpi.com
This review integrates the currently available information on the molecular, cellular, and
systemic mechanisms involved in the pathophysiology of preeclampsia. It highlights that the …

[HTML][HTML] Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia

A Hufnagel, L Dearden… - Journal of …, 2022 - joe.bioscientifica.com
Obesity and gestational diabetes during pregnancy have multiple short-and long-term
consequences for both mother and child. One common feature of pregnancies complicated …

Understanding abnormal uterine artery Doppler waveforms: a novel computational model to explore potential causes within the utero-placental vasculature

AR Clark, JL James, GN Stevenson, SL Collins - Placenta, 2018 - Elsevier
Abstract Introduction Uterine artery (UtA) Doppler indices are one of the most commonly
employed screening tests for pre-eclampsia worldwide. Abnormal indices appear to result …

The effect of maternal position on placental blood flow and fetoplacental oxygenation in late gestation fetal growth restriction: a magnetic resonance imaging study

D Jani, A Clark, S Couper… - The Journal of …, 2023 - Wiley Online Library
Fetal growth restriction (FGR) and maternal supine going‐to‐sleep position are both risk
factors for late stillbirth. This study aimed to use magnetic resonance imaging (MRI) to …