Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …

Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …

Scientists have made significant progress in understanding and unraveling several aspects
of double‐stranded RNA (dsRNA)‐mediated gene silencing during the last two decades …

RNA interference (RNAi) is a biological process in which small RNA (sRNA) molecules
sequence-specifically silence gene expression at the transcriptional or post-transcriptional …

RNAi is a potent technique for the knockdown of target genes. However, its potential off-
target effects limit the widespread applications in both reverse genetic analysis and genetic …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

Many antisense oligonucleotides (ASOs) from several classes of molecules are currently in
drug development. Despite over 20 years of pharmaceutical research, few ASOs have been …

The discovery that gene expression can be controlled by the Watson–Crick base-pairing of
small RNAs with messenger RNAs containing complementary sequence—a process known …

Transfected siRNAs and miRNAs regulate numerous transcripts that have only limited
complementarity to the active strand of the RNA duplex. This process reflects natural target …

Morpholino phosphorodiamidate antisense oligonucleotides (MOs) and short interfering
RNAs (siRNAs) are commonly used platforms to study gene function by sequence-specific …