Remarkable progress has been made in the development of new therapies for cancer,
dramatically changing the landscape of treatment approaches for several malignancies and …

Fluoropyrimidines such as 5-fluorouracil (5-FU) form the foundation of a wide variety of
chemotherapy regimens. 5-FU is in fact the third most commonly used chemotherapeutic …

Regenerative capacity declines throughout evolution and with age. In this study, we asked
whether metabolic programs underlying regenerative capability might be conserved across …

Diarrhoea is defined as the frequent passage of loose stools with urgency (or more frequent
passage than is normal for the individual). Objectively defined, it is the passage of more than …

As medicine advances to employ sophisticated anticancer agents to treat a vast array of
oncological conditions, it is worth considering side effects associated with several …

5‐Fluorouracil (5‐FU) is dosed by body surface area, a practice unable to reduce the
interindividual variability in exposure. Endorsed by the International Association of …

Abstract Purpose of Review 5-fluorouracil (5-FU) is one of the most common causes of
cardiotoxicity associated with chemotherapy. The manifestations of 5-FU cardiotoxicity are …

While there have been rapid advances in developing new and more targeted drugs to treat
cancer, much less progress has been made in individualizing dosing. Even though the …

The fluoropyrimidines, namely 5-fluorouracil (5-FU) and its oral prodrug, capecitabine, are
the third most commonly used chemotherapeutic agents for the treatment of solid tumors of …

PURPOSE Patients who carry pathogenic variants in DPYD have higher systemic
fluoropyrimidine (FP) concentrations and greater risk of severe and fatal FP toxicity …