Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Evaluating the atrial myopathy underlying atrial fibrillation: identifying the arrhythmogenic and thrombogenic substrate

JJ Goldberger, R Arora, D Green, P Greenland… - Circulation, 2015 - Am Heart Assoc
Atrial disease or myopathy forms the substrate for atrial fibrillation (AF) and underlies the
potential for atrial thrombus formation and subsequent stroke. Current diagnostic …

Lone atrial fibrillation: does it exist?

DG Wyse, IC Van Gelder, PT Ellinor, AS Go… - Journal of the American …, 2014 - jacc.org
The historical origin of the term “lone atrial fibrillation”(AF) predates by 60 years our current
understanding of the pathophysiology of AF, the multitude of known etiologies for AF, and …

Diastolic dysfunction and risk of atrial fibrillation: a mechanistic appraisal

MA Rosenberg, WJ Manning - Circulation, 2012 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia, and its prevalence in the
population is increasing. 1 Diastolic dysfunction shares many common risk factors with AF …

Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts

S Ghavami, B Yeganeh, AA Zeki… - … of Physiology-Lung …, 2018 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited
treatment options. Autophagy and the unfolded protein response (UPR), fundamental …

A novel reciprocal loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis

H Liang, C Zhang, T Ban, Y Liu, L Mei, X Piao… - The international journal …, 2012 - Elsevier
Cardiac fibrosis is characterized by aberrant proliferation of cardiac fibroblasts and
exaggerated deposition of extracellular matrix (ECM) in the myocardial interstitial, and …

Atrial fibrosis as a dominant factor for the development of atrial fibrillation: facts and gaps

A Xintarakou, S Tzeis, S Psarras, D Asvestas… - EP …, 2020 - academic.oup.com
Atrial fibrillation (AF), the most commonly diagnosed arrhythmia, affects a notable
percentage of the population and constitutes a major risk factor for thromboembolic events …

The relationship between atrial fibrillation and coronary artery disease: Understanding common denominators

M Mekhael, N Marrouche, AH El Hajjar… - Trends in cardiovascular …, 2022 - Elsevier
Atrial fibrillation (AF) and coronary artery disease (CAD) are highly prevalent cardiovascular
conditions. The coexistence of both diseases is common as they share similar risk factors …

[HTML][HTML] MicroRNA-101a inhibits cardiac fibrosis induced by hypoxia via targeting TGFβRI on cardiac fibroblasts

X Zhao, K Wang, Y Liao, Q Zeng, Y Li, F Hu… - Cellular Physiology and …, 2015 - karger.com
Background/Aims: Hypoxia is a basic pathological challenge that is associated with
numerous cardiovascular disorders including aberrant cardiac remodeling. Transforming …

Angiotensin II increases CTGF expression via MAPKs/TGF-β1/TRAF6 pathway in atrial fibroblasts

J Gu, X Liu, Q Wang, H Tan, M Guo, W Jiang… - Experimental cell …, 2012 - Elsevier
The activation of transforming growth factor-β1 (TGF-β1)/Smad signaling pathway and
increased expression of connective tissue growth factor (CTGF) induced by angiotensin II …