Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …

Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …

Hallucinations limit widespread therapeutic use of psychedelics as rapidly acting
antidepressants. Here we profiled the non-hallucinogenic lysergic acid diethylamide (LSD) …

Simple Summary Scientists use animal models to study the mechanisms of human diseases
and find new drugs to treat them. Chronic Unpredictable Mild Stress is the best animal …

Aggression and deficient cognitive control problems are widespread in psychiatric disorders,
including major depressive disorder (MDD). These abnormalities are known to contribute …

Understanding the individual variability that comes with the likelihood of developing stress-
related psychopathologies is of paramount importance when addressing mechanisms of …

Background Major depressive disorder (MDD) is a prevalent and devastating psychiatric
illness. Unfortunately, the current therapeutic practice, generally depending on the …

Background: Stress can lead to emotional and mental symptoms such as anxiety, sadness,
panic attacks, and depression. Malic acid was chosen due to malic acid has the ability to …

The phenomenon of individual variability in susceptibility/resilience to stress and
depression, in which the hippocampus plays a pivotal role, is attracting increasing attention …

Major depressive disorder is a common psychiatric condition often resistant to medication.
The Wistar-Kyoto (WKY) rat has been suggested as an animal model of depression; …