Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration
Q Zhao, Y Zheng, D Zhao, L Zhao, L Geng, S Ma… - Protein & …, 2023 - academic.oup.com
Hair loss affects millions of people at some time in their life, and safe and efficient treatments
for hair loss are a significant unmet medical need. We report that topical delivery of quercetin …
for hair loss are a significant unmet medical need. We report that topical delivery of quercetin …
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of Rev1 and Polq in mouse embryonic stem cells
F Jiang, L Wang, Y Dong, W Nie… - Proceedings of the …, 2023 - National Acad Sciences
Genetic alterations are often acquired during prolonged propagation of pluripotent stem
cells (PSCs). This ruins the stem cell quality and hampers their full applications …
cells (PSCs). This ruins the stem cell quality and hampers their full applications …
[HTML][HTML] Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube
The human fallopian tube harbors the cell of origin for the majority of high-grade serous"
ovarian" cancers (HGSCs), but its cellular composition, particularly the epithelial component …
ovarian" cancers (HGSCs), but its cellular composition, particularly the epithelial component …
[HTML][HTML] A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing
As part of the Human Cell Atlas Initiative, our goal is to generate single-cell transcriptomics
(single-cell RNA sequencing [scRNA-seq], 86,708 cells) and regulatory (single-cell assay on …
(single-cell RNA sequencing [scRNA-seq], 86,708 cells) and regulatory (single-cell assay on …
Advanced Oxidation Protein Products Induce G1/G0‐Phase Arrest in Ovarian Granulosa Cells via the ROS‐JNK/p38 MAPK‐p21 Pathway in Premature Ovarian …
XY Zhou, J Zhang, Y Li, YX Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
The mechanism underlying the role of oxidative stress and advanced oxidation protein
products (AOPPs) in the aetiology of premature ovarian insufficiency (POI) is poorly …
products (AOPPs) in the aetiology of premature ovarian insufficiency (POI) is poorly …
[HTML][HTML] Single-cell transcriptome dissection of the toxic impact of Di (2-ethylhexyl) phthalate on primordial follicle assembly
Rationale: Accumulated evidence indicates that environmental plasticizers are a threat to
human and animal fertility. Di (2-ethylhexyl) phthalate (DEHP), a plasticizer to which humans …
human and animal fertility. Di (2-ethylhexyl) phthalate (DEHP), a plasticizer to which humans …
Chitosan Oligosaccharides Alleviate H2O2‐stimulated Granulosa Cell Damage via HIF‐1α Signaling Pathway
Z Yang, W Hong, K Zheng, J Feng, C Hu… - Oxidative Medicine …, 2022 - Wiley Online Library
Oocyte maturation disorder and decreased quality are the main causes of infertility in
women, and granulosa cells (GCs) provide the only microenvironment for oocyte maturation …
women, and granulosa cells (GCs) provide the only microenvironment for oocyte maturation …
[HTML][HTML] Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy
Primary ovarian insufficiency (POI) is an ovarian dysfunction that affects more than 1% of
women and is characterized by hormone imbalances that afflict women before the age of 40 …
women and is characterized by hormone imbalances that afflict women before the age of 40 …
A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats
L Geng, B Zhang, H Liu, S Wang, Y Cai, K Yang… - Life …, 2023 - academic.oup.com
Metformin (MET) and nicotinamide riboside (NR) have both been reported to exert
geroprotective effects in multiple species. However, the mechanism by which MET and NR …
geroprotective effects in multiple species. However, the mechanism by which MET and NR …
Single-nucleus transcriptomic landscape of primate hippocampal aging
The hippocampus plays a crucial role in learning and memory, and its progressive
deterioration with age is functionally linked to a variety of human neurodegenerative …
deterioration with age is functionally linked to a variety of human neurodegenerative …