Neuropathic pain: mechanisms and their clinical implications
Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …
neurons and along nociceptive and descending modulatory pathways in the central nervous …
Opioid-induced hyperalgesia: cellular and molecular mechanisms
LA Roeckel, GM Le Coz, C Gavériaux-Ruff, F Simonin - Neuroscience, 2016 - Elsevier
Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …
[HTML][HTML] Role of IL-6 in the regulation of neuronal development, survival and function
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …
and destructive potentials. It can exert opposing actions triggering either neuron survival …
[HTML][HTML] Diabetic neuropathic pain: physiopathology and treatment
AK Schreiber, CFM Nones, RC Reis… - World journal of …, 2015 - ncbi.nlm.nih.gov
Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …
Biological hypotheses and biomarkers of bipolar disorder
E Sigitova, Z Fišar, J Hroudová… - Psychiatry and …, 2017 - Wiley Online Library
The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …
Characterisation of immune and neuroinflammatory changes associated with chemotherapy-induced peripheral neuropathy
PGS Makker, SS Duffy, JG Lees, CJ Perera, RS Tonkin… - PloS one, 2017 - journals.plos.org
Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …
Salivary markers of inflammation in response to acute stress
There is burgeoning interest in the ability to detect inflammatory markers in response to
stress within naturally occurring social contexts and/or across multiple time points per day …
stress within naturally occurring social contexts and/or across multiple time points per day …
Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action
Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers
an implantable, non-pharmacologic treatment for patients with intractable chronic pain …
an implantable, non-pharmacologic treatment for patients with intractable chronic pain …
The role of microglia in the pathobiology of neuropathic pain development: what do we know?
Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
Histamine, histamine receptors, and neuropathic pain relief
I Obara, V Telezhkin, I Alrashdi… - British Journal of …, 2020 - Wiley Online Library
Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …
physiological and pathological processes, including pain. In the last two decades, there has …