Neuropathic pain can develop after nerve injury, when deleterious changes occur in injured
neurons and along nociceptive and descending modulatory pathways in the central nervous …

Opioids produce strong analgesia but their use is limited by a paradoxical hypersensitivity
named opioid-induced hyperalgesia (OIH) that may be associated to analgesic tolerance. In …

The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes, which
affects over 90% of the diabetic patients. Although pain is one of the main symptoms of …

The most common mood disorders are major depressive disorders and bipolar disorders
(BD). The pathophysiology of BD is complex, multifactorial, and not fully understood …

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …

There is burgeoning interest in the ability to detect inflammatory markers in response to
stress within naturally occurring social contexts and/or across multiple time points per day …

Well-established in the field of bioelectronic medicine, Spinal Cord Stimulation (SCS) offers
an implantable, non-pharmacologic treatment for patients with intractable chronic pain …

Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …

Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …