The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-
1 reverse transcriptase and are classified into generations depending on their discovery and …

Introduction: There is a continuous need for next-generation non-nucleoside RT inhibitors
(NNRTIs) with different resistance profiles, improved safety, excellent tolerability, and …

Impacts of mutations at position E138 (A/G/K/Q/R/V) alone or in combination with M184I in
HIV-1 reverse transcriptase (RT) were investigated. We also determined why E138K is the …

Diarylpyrimidines (DAPYs), acting as HIV-1 nonnucleoside reverse transcriptase inhibitors
(NNRTIs), have been considered to be one of the most potent drug families in the fight …

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are recommended components of
preferred combination antiretroviral therapies used for the treatment of human …

Friedreich ataxia is a rare neurodegenerative disorder caused by insufficient levels of the
essential mitochondrial protein frataxin. It is a severely debilitating disease that significantly …

Although decreasing in prevalence, heavily treatment-experienced (HTE) persons with
limited options for HIV treatment present unique complexities, even amongst experienced …

Non‐nucleoside reverse transcriptase inhibitors (NNRTIs) have always been an important
part of the anti‐HIV‐1 combination therapy known as combination antiretroviral therapy …

Rilpivirine and etravirine are second generation non-nucleoside reverse transcriptase
inhibitors approved recently by the United States Food and Drug Administration for the …

Abstract N 1-ary-benzimidazol (NABZ) derivatives, an important class of HIV-1
nonnucleoside reverse transcriptase inhibitors (NNRTIs), have been considered as one of …