Microbiota and maintenance of skin barrier function

TA Harris-Tryon, EA Grice - Science, 2022 - science.org
Human skin forms a protective barrier against the external environment and is our first line of
defense against toxic, solar, and pathogenic insults. Our skin also defines our outward …

Mass spectrometry-based metabolomics in microbiome investigations

A Bauermeister, H Mannochio-Russo… - Nature Reviews …, 2022 - nature.com
Microbiotas are a malleable part of ecosystems, including the human ecosystem.
Microorganisms affect not only the chemistry of their specific niche, such as the human gut …

Staphylococcus epidermidis and its dual lifestyle in skin health and infection

MM Severn, AR Horswill - Nature Reviews Microbiology, 2023 - nature.com
The coagulase-negative bacterium Staphylococcus epidermidis is a member of the human
skin microbiota. S. epidermidis is not merely a passive resident on skin but actively primes …

Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials

S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Skin barrier function and the microbiome

HJ Lee, M Kim - International journal of molecular sciences, 2022 - mdpi.com
Human skin is the largest organ and serves as the first line of defense against environmental
factors. The human microbiota is defined as the total microbial community that coexists in the …

The microbiome-shaping roles of bacteriocins

S Heilbronner, B Krismer, H Brötz-Oesterhelt… - Nature Reviews …, 2021 - nature.com
The microbiomes on human body surfaces affect health in multiple ways. They include not
only commensal or mutualistic bacteria but also potentially pathogenic bacteria, which can …

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection

N Smith, P Goncalves, B Charbit, L Grzelak… - Nature …, 2021 - nature.com
Coordinated local mucosal and systemic immune responses following severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against …

Microbiome epidemiology and association studies in human health

H VanEvery, EA Franzosa, LH Nguyen… - Nature Reviews …, 2023 - nature.com
Studies of the human microbiome share both technical and conceptual similarities with
genome-wide association studies and genetic epidemiology. However, the microbiome has …

Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra

AM King, Z Zhang, E Glassey, P Siuti, J Clardy… - Nature …, 2023 - nature.com
Human-associated bacteria secrete modified peptides to control host physiology and
remodel the microbiota species composition. Here we scanned 2,229 Human Microbiome …

[HTML][HTML] Anatomy promotes neutral coexistence of strains in the human skin microbiome

A Conwill, AC Kuan, R Damerla, AJ Poret, JS Baker… - Cell Host & Microbe, 2022 - cell.com
What enables strains of the same species to coexist in a microbiome? Here, we investigate
whether host anatomy can explain strain co-residence of Cutibacterium acnes, the most …