PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

▪ Abstract Vascular endothelium is strategically located at the interface between tissue and
blood. It is pivotal for protecting against vascular injury and maintaining blood fluidity …

Following vascular injury, blood loss is controlled by the mechanisms of hemostasis. During
this process, the serine proteinase, thrombin, is generated both locally and rapidly at sites of …

Although familial clustering of venous thromboembolic events was observed at the start of
this century, it was not until the late nineteenseventies before our insight into the …

The negatively charged aminophospholipid, phosphatidylserine (PtdSer), is located in the
inner leaflet of the plasma membrane in normal cells, and may be exposed to the outer …

Background: Beside the often discussed topics of consumption and dilution coagulopathy,
additional perioperative impairments of coagulation are caused by acidosis, hypocalcemia …

Following initiation of coagulation as part of the hemostatic response to injury, thrombin is
generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase …

It has long been appreciated that lipids, particularly anionic phospholipids, promote blood
coagulation. The last two decades have seen an increasing insight into the kinetic and …

The protein C anticoagulant system generates an “on demand” physiologic anticoagulant
response. The pathway is initiated when thrombin binds to the endothelial cell thrombin …

The vascular endothelial cell forms a semipermeable barrier between blood and interstitium.
Inflammatory mediators such as thrombin and histamine induce vascular leakage defined as …