Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
intravascular fibrin formation occurring in the course of a variety of severe diseases. In Gram …

Objectives: To establish the threshold value for calcium at which coagulation commenced
and to investigate the range over which changes in ionized calcium influenced coagulation …

Activation of protease-activated receptor 1 (PAR1) by activated protein C (APC) and
thrombin elicits paradoxical cytoprotective and cytotoxic signaling responses in vascular …

Precise modulation of thrombin activity throughout the hemostatic response is essential for
efficient cessation of bleeding while preventing inappropriate clot growth or dissemination …

Summary Background: Activated protein C (APC) is a vitamin K‐dependent plasma serine
protease that down‐regulates clotting and inflammatory pathways. It is known that APC …

When the continuity of the vascular endothelium is disrupted, platelets and fibrin seal off the
defect. Haemostatic processes are classified as primary (mainly involving platelets) and …

The heart is a very special organ in the body and has a high requirement for metabolism due
to its constant workload. As a consequence, to provide a consistent and sufficient energy a …

We recently demonstrated that the occupancy of endothelial protein C receptor (EPCR) by
its natural ligand activated protein C (APC)/protein C switches the protease activated …

Blood coagulation is a response to vascular injury leading to the activation of platelets and
coagulation factors with the ultimate formation of a fibrin plug. Several coagulation factors …

The blood coagulation cascade is regulated by the luminal surface of the endothelial cell
lining. 1 Endothelial cells synthesize tissue factor pathway inhibitor (TFPI), which, in part …