Given the central role of thrombin in arterial thrombogenesis, most treatment strategies for
acute coronary syndromes are aimed at inhibiting its generation or blocking its activity …

We evaluated systemic alterations to the blood coagulation system that occur during a
coronary thrombotic event. Peripheral blood coagulation in patients with acute coronary …

Background: The endothelial protein C receptor (EPCR)-dependent cleavage of protease
activated receptor 1 (PAR-1) by either activated protein C (APC) or thrombin in lipid rafts …

The Endometrium is devoted to a comprehensive multi-disciplinary account of the uterine
endometrium. This book is the first to define the regulatory biological interrelationships …

Background: Impairment of intestinal barrier function and increased translocation of bacteria
to the systemic blood flow contribute to the emergence of sepsis. Probiotics might be of …

Thromboembolic disease (TED) in the venous and arterial vascular system plays an
important role in the pathogenesis of various cardiovascular disorders and is responsible for …

It has been hypothesized that the protein C pathway is a pivotal link between the
inflammation and coagulation cascades. The demonstration that a survival benefit is …

Objective We aimed to characterize the pharmacokinetics and pharmacodynamics of
drotrecogin alfa (activated)(recombinant human activated protein C) in patients with severe …

Several recent studies have demonstrated that the activation of protease‐activated receptor
1 (PAR‐1) by thrombin and activated protein C (APC) on cultured vascular endothelial cells …

Abstract Circulating levels of Brain Derived Neurotrophic Factor (BDNF) are lower in
coronary heart disease (CHD) than in healthy subjects and are associated with coronary …