We evaluated the antithrombotic effects of recombinant human soluble thrombomodulin
(rhsTM) in plasma and in a monkey model. rhsTM dose-dependently prolonged activated …

Background The coronavirus disease 2019 (COVID‐19) pandemic has caused a large
surge of acute respiratory distress syndrome (ARDS). Prior phase I trials (non–COVID‐19) …

Pulmonary microvascular injury, one of the earliest events in adult respiratory distress
syndrome (ARDS), is caused by the release of injurious products from stimulated neutrophils …

Thrombosis is the major cause of early vein graft failure. Our aim was to determine whether
alterations in the expression of the anticoagulant proteins, thrombomodulin (TM) and the …

Studies have been carried out to investigate aspects of the structure of thrombomodulin, an
endothelial cell glycoprotein that binds thrombin and accelerates both the thrombin …

Inherited resistance to activated protein C (APC) is the most common genetic risk factor of
venous thrombosis. It is caused by a single point mutation in the factor (F) V gene which …

We recently demonstrated that the Gla domain-dependent interaction of protein C with
endothelial protein C receptor (EPCR) leads to dissociation of the receptor from caveolin-1 …

The levels of circulating activated protein C (APC) reflect in vivo protein C activation. The
aim of this study was to determine whether a low APC level is an independent risk factor for …

The occupancy of endothelial protein C receptor (EPCR) by protein C switches the protease
activated receptor 1 (PAR-1)-dependent signalling specificity of thrombin from a permeability …

Hereditary thrombophilia was first described in 1965, in a Norwegian family with decreased
antithrombin activity (1), demonstrating the physiological importance of circulating …