Abstract Human proximal tubule (HK‐2) cells are commonly used as cellular models to
understand the mechanism by which inflammatory mediators cause renal injury. It has been …

Thrombomodulin (TM) is an anionic (pI approximately 4) protein cofactor that promotes
thrombin (THR) cleavage of protein C to generate activated protein C (APC), a potent …

The coagulation cascade is controlled by several anticoagulant safeguards that avoid
excessive clot formation. Disorders of these anticoagulant mechanisms are an important …

Deficiency of antithrombin (AT), protein C (PC) or protein S (PS) constitutes a major risk
factor for venous thromboembolism (VTE). Individuals at high risk for recurrence who benefit …

The major hematological changes during pregnancy are physiologic anemia, neutrophilia,
mild thrombocytopenia, increased procoagulant factors, and diminished fibrinolysis. Plasma …

Objective—Thrombin is the key serine protease of the coagulation cascade and mediates
cellular responses by activation of PARs (protease-activated receptors). The predominant …

Abstract Prof. Tage Astrup first elaborated the notion that blood fluidity involved a balance
between the tendency of blood to clot and for such clots to lyse. It would seem that, at that …

Introduction Trauma patients receiving massive transfusion protocol (MTP) are at risk of
citrate-induced hypocalcemia and hyperkalemia. Here we evaluate potassium (K), ionized …

The role of basic residues of the 70− 80-loop, Arg74, Arg75, and Lys78 (chymotrypsin
numbering) in the catalytic function of activated protein C (APC) was investigated by …

Reduction in host-activated protein C levels and resultant microvascular thrombosis
highlight the important functional role of protein C anticoagulant system in the pathogenesis …