Autism spectrum disorder (ASD) is a heterogeneous, behaviorally defined
neurodevelopmental disorder. Over the past two decades, the prevalence of autism …

In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …

Chronic social isolation stress during adolescence induces susceptibility for
neuropsychiatric disorders. Here we show that 5-week post-weaning isolation stress …

The medial prefrontal cortex and amygdala are involved in the regulation of social behavior
and associated with psychiatric diseases but their detailed neurophysiological mechanisms …

ASH1L, a histone methyltransferase, is identified as a top-ranking risk factor for autism
spectrum disorder (ASD), however, little is known about the biological mechanisms …

Valproic acid (VPA) exposure as an environmental factor that confers risk of autism spectrum
disorder (ASD), its functional mechanisms in the human brain remain unclear since relevant …

ADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-
remodeling complex, is characterized by developmental delay, intellectual disability, and …

Pleiotropic mechanisms have been implicated in Alzheimer's disease (AD), including
transcriptional dysregulation, protein misprocessing and synaptic dysfunction, but how they …

With increasing maternal cannabis use, there is a need to investigate the lasting impact of
prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main psychotropic compound in …

Prefrontal cortex (PFC) inhibitory microcircuits regulate the gain and timing of pyramidal
neuron firing, coordinate neural ensemble interactions, and gate local and long-range …