Genetic addiction risk severity assessment identifies polymorphic reward genes as antecedents to reward deficiency syndrome (RDS) hypodopaminergia's effect on …
CA Dennen, K Blum, A Bowirrat, PK Thanos… - Journal of Personalized …, 2022 - mdpi.com
This case series presents the novel genetic addiction risk score (GARS), which shows a high
prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple …
prevalence of polymorphic risk alleles of reward genes in a nuclear family with multiple …
[HTML][HTML] Heightened SAM-and HPA-axis activity during acute stress impairs decision-making: A systematic review on underlying neuropharmacological mechanisms
L van Herk, FPM Schilder, AD de Weijer… - Neurobiology of …, 2024 - Elsevier
Individuals might be exposed to intense acute stress while having to make decisions with far-
reaching consequences. Acute stress impairs processes required for decision-making by …
reaching consequences. Acute stress impairs processes required for decision-making by …
Disturbed relationship between glucocorticoid receptor and 5-HT1AR/5-HT2AR in ADHD rats: A correlation study
X Lin, L Huang, H Huang, Z Ke, Y Chen - Frontiers in Neuroscience, 2023 - frontiersin.org
Objective This work is to investigate the alterations of the central 5-hydroxytryptamine (5-HT)
system in spontaneously hypertensive rats (SHR) and the correlation with the behaviors of …
system in spontaneously hypertensive rats (SHR) and the correlation with the behaviors of …
Network pharmacology, molecular docking, and experimental validation to explore the potential mechanism of Long Mu Qing Xin mixture for the treatment of attention …
X Li, Z Xiao, W Pu, Z Jiang, S Wang… - Frontiers in …, 2023 - frontiersin.org
Background: Long Mu Qing Xin Mixture (LMQXM) has shown potentially positive effects in
alleviating attention deficit hyperactivity disorder (ADHD); however, the action mechanism is …
alleviating attention deficit hyperactivity disorder (ADHD); however, the action mechanism is …
Common and Distinct Disruptions of Cortical Surface Morphology Between Autism Spectrum Disorder Children With and Without SHANK3 Deficiency
D Li, C Liu, Z Huang, H Li, Q Xu, B Zhou, C Hu… - Frontiers in …, 2021 - frontiersin.org
SH3 and Multiple Ankyrin Repeat Domains 3 (SHANK3)-caused autism spectrum disorder
(ASD) may present a unique opportunity to clarify the heterogeneous neuropathological …
(ASD) may present a unique opportunity to clarify the heterogeneous neuropathological …
Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs
F Zhu, Q Shi, Y Jiang, YQ Zhang, H Zhao - Molecular Autism, 2024 - Springer
Background SHANK3 gene is a highly replicated causative gene for autism spectrum
disorder and has been well characterized in multiple Shank3 mutant rodent models. When …
disorder and has been well characterized in multiple Shank3 mutant rodent models. When …
Adolescent stress differentially modifies dopamine and norepinephrine release in the medial prefrontal cortex of adult rats
E Carboni, M Ibba, E Carboni, AR Carta - Progress in Neuro …, 2024 - Elsevier
Adolescent stress (AS) has been associated with higher vulnerability to psychiatric disorders
such as schizophrenia, depression, or drug dependence. Moreover, the alteration of brain …
such as schizophrenia, depression, or drug dependence. Moreover, the alteration of brain …
Chronic social defeat stress induces the down‐regulation of the Nedd4L‐GLT‐1 ubiquitination pathway in the prefrontal cortex of mice
A Kosuge, K Kunisawa, T Iida, B Wulaer… - Journal of …, 2024 - Wiley Online Library
Stressful life events contribute to the onset of major depressive disorder (MDD). We recently
demonstrated abnormalities in ubiquitination in the pathophysiology of MDD. However, the …
demonstrated abnormalities in ubiquitination in the pathophysiology of MDD. However, the …
Transcutaneous vagus nerve stimulation modulates depression‐like phenotype induced by high‐fat diet via P2X7R/NLRP3/IL‐1β in the prefrontal cortex
S Li, Y Zhang, Y Wang, Z Zhang, C Xin… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Depression is a common psychiatric disorder in diabetic patients. Depressive
mood associated with obesity/metabolic disorders is related to the inflammatory response …
mood associated with obesity/metabolic disorders is related to the inflammatory response …
M1/M4 receptors as potential therapeutic treatments for schizophrenia: A comprehensive study
L Fu, Y Luo, L Niu, Y Lin, X Chen, J Zhang… - Bioorganic & Medicinal …, 2024 - Elsevier
Muscarinic acetylcholine receptors (mAChRs) play a significant role in the pathophysiology
of schizophrenia. Although activating mAChRs holds potential in addressing the full range of …
of schizophrenia. Although activating mAChRs holds potential in addressing the full range of …