Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …

Epigenetic mechanisms play vital roles not only in cancer initiation and progression, but also
in the activation, differentiation and effector function (s) of immune cells. In this review, we …

Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …

Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …

Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma
treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived …

Oxygen, which is necessary for sustaining energy metabolism, is consumed in many
biochemical reactions in eukaryotes. When the oxygen supply is insufficient for maintaining …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Studies in human microbiota dysbiosis have shown that short-chain fatty acids (SCFAs) like
propionate, acetate, and particularly butyrate, positively affect energy homeostasis …

The inter-neuronal communication occurring in extensively branched neuronal cells is
achieved primarily through the microtubule (MT)-mediated axonal transport system. This …

Histone deacetylase (HDAC) inhibitors used in the clinic typically contain a hydroxamate
zinc-binding group (ZBG). However, more recent work has shown that the use of alternative …