Paracrine mechanisms of mesenchymal stem cells in tissue repair

M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

[HTML][HTML] Pathophysiology of acute kidney injury

DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

W Nassar, M El-Ansary, D Sabry, MA Mostafa… - Biomaterials …, 2016 - spj.science.org
Background Bio-products from stem/progenitor cells, such as extracellular vesicles, are
likely a new promising approach for reprogramming resident cells in both acute and chronic …

Cisplatin‐induced rodent model of kidney injury: characteristics and challenges

M Perše, Ž Večerić-Haler - BioMed research international, 2018 - Wiley Online Library
Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies.
However, its primary dose‐limiting side effect is kidney injury, which is a major clinical …

[HTML][HTML] Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in …

Y Zhou, H Xu, W Xu, B Wang, H Wu, Y Tao… - Stem cell research & …, 2013 - Springer
Introduction Administration of bone marrow mesenchymal stem cells (MSCs) or secreted
microvesicles improves recovery from acute kidney injury (AKI). However, the potential roles …

[HTML][HTML] RETRACTED: engineered whole organs and complex tissues

SF Badylak, DJ Weiss, A Caplan, P Macchiarini - The Lancet, 2012 - thelancet.com
End-stage organ failure is a key challenge for the medical community because of the ageing
population and the severe shortage of suitable donor organs available. Equally, injuries to …

Natural history of mesenchymal stem cells, from vessel walls to culture vessels

IR Murray, CC West, WR Hardy, AW James… - Cellular and Molecular …, 2014 - Springer
Mesenchymal stem/stromal cells (MSCs) can regenerate tissues by direct differentiation or
indirectly by stimulating angiogenesis, limiting inflammation, and recruiting tissue-specific …

[HTML][HTML] Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art

A Malgieri, E Kantzari, MP Patrizi… - International journal of …, 2010 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are multipotent adult stem cells present in all tissues, as
part of the perivascular population. As multipotent cells, MSCs can differentiate into different …

3D spheroid culture enhances survival and therapeutic capacities of MSC s injected into ischemic kidney

Y Xu, T Shi, A Xu, L Zhang - Journal of cellular and molecular …, 2016 - Wiley Online Library
Abstract Three‐dimensional (3D) cell culture has been reported to increase the therapeutic
potentials of mesenchymal stem cells (MSC s). In this study, we aimed to investigate the …

Perivascular ancestors of adult multipotent stem cells

M Corselli, CW Chen, M Crisan, L Lazzari… - … , and vascular biology, 2010 - Am Heart Assoc
Independent studies by numerous investigators have shown that it is possible to harvest
multipotent progenitor cells from diverse dissociated and cultured fetal, perinatal, and …