Resolved and unresolved issues in the prevention and treatment of coronary artery disease: a workshop consensus statement

V Dzau, E Braunwald - American heart journal, 1991 - Elsevier
Advances in cardiovascular research during the past two decades have resulted in an
improved understanding of the chain of events that lead to end-stage coronary artery …

Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection.

EM Lonn, S Yusuf, P Jha, TJ Montague, KK Teo… - Circulation, 1994 - Am Heart Assoc
A ngiotensin-converting enzyme (ACE) inhibitors are commonly used drugs in the
management of a variety of cardiovascular diseases. They are effective antihypertensive …

Reversal of left ventricular hypertrophy in hypertensive patients: a metaanalysis of 109 treatment studies

B Dahlöf, K Pennert, L Hansson - 1992 - academic.oup.com
This is a metaanalysis of all available studies as of December 1990 that have evaluated the
effect of antihypertensive pharmacologic therapy on left ventricular structure examined by …

Brain angiotensin receptor subtypes in the control of physiological and behavioral responses

JW Wright, JW Harding - Neuroscience & Biobehavioral Reviews, 1994 - Elsevier
This review summarizes emerging evidence that supports the notion of a separate brain
renin-angiotensin system (RAS) complete with the necessary precursors and enzymes for …

A comparison of the efficacy and safety of a β-blocker, a calcium channel blocker, and a converting enzyme inhibitor in hypertensive blacks

E Saunders, MR Weir, BW Kong… - Archives of internal …, 1990 - jamanetwork.com
A double-blind, positively controlled, forced dose titration study comparing the efficacy and
safety of atenolol, captopril, and verapamil sustained release as single agents in the …

Regulatory role of brain angiotensins in the control of physiological and behavioral responses

JW Wright, JW Harding - Brain Research Reviews, 1992 - Elsevier
Considerable evidence now indicates that a separate and distinct renin-angiotensin system
(RAS) is present within the brain. The necessary precursors and enzymes required for the …

Brain angiotensin receptor subtypes AT1, AT2, and AT4 and their functions

JW Wright, JW Harding - Regulatory peptides, 1995 - Elsevier
The discovery of at least four angiotensin receptor subtypes, three of which are distributed in
the brain as well as peripheral tissues, and the availability of nonpeptide angiotensin …

Heart failure with normal systolic function: a common disorder in older people

DD Tresch, MF McGough - Journal of the American Geriatrics …, 1995 - Wiley Online Library
OBJECTIVE: To review the incidence, pathophysiology, significance, diagnosis, and
treatment of heart failure with normal systolic function in older patients DATA SOURCE …

Captopril: an update of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension and congestive heart failure

RN Brogden, PA Todd, EM Sorkin - Drugs, 1988 - Springer
Captopril is an orally active inhibitor of angiotensin-converting enzyme (ACE) and has been
widely studied in the treatment of patients with mild to moderate essential hypertension …

Beneficial effects of captopril in acute coxsackievirus B3 murine myocarditis.

S Rezkalla, RA Kloner, G Khatib, R Khatib - Circulation, 1990 - Am Heart Assoc
To date, there is no universally accepted therapy for viral myocarditis. We investigated the
effect of the angiotensin converting enzyme inhibitor captopril on both early and late phases …