Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …

Abstract Cell-penetrating peptide (CPP)-mediated intracellular drug delivery system, often
specifically termed as “the Trojan horse approach”, has become the “holy grail” in achieving …

Abstract Haloalkane dehalogenases (EC 3.8. 1.5, HLDs) are α/β‐hydrolases which act to
cleave carbon‐halogen bonds. Due to their unique catalytic mechanism, broad substrate …

We developed a novel near-infrared (NIR) fluorescent probe, GPU-167, for in vivo imaging
of tumor hypoxia. GPU-167 comprises a tricarbocyanine dye as an NIR fluorophore and two …

The properties of gold nanomaterials are particularly of interest to many researchers, since
they show unique physiochemical properties such as optical adsorption of specific …

In vivo sensors are an emerging field with the potential to revolutionize our understanding of
basic biology and our treatment of disease. In this review, we highlight recent advances in …

Advances in fluorescence microscopy have enabled the study of membrane diffusion, cell
adhesion and signal transduction at the molecular level in living cells grown in culture. By …

Abstract Cell-penetrating peptides (CPPs), also referred to as protein transduction domains
(PTDs), can mediate the cellular uptake of a wide range of macromolecules including …

Usage of the enhanced green fluorescent protein (eGFP) in living mammalian cells is limited
to aerobic conditions due to requirement of oxygen during chromophore formation. Since …

Hypoxia is a typical hallmark of various diseases, including cancer, ischemic diseases, and
stroke. It is also associated with the disease progression. Therefore, it is critical to develop …