Background N-acetylcysteine (NAC) has been suggested to prevent relapse to cocaine
seeking. However, the psychological processes underlying its potential therapeutic benefit …

Rationale Effective pharmacological treatments to prevent cocaine relapse remain elusive.
In male rats, ceftriaxone attenuates the reinstatement of cocaine-seeking while increasing …

In drug addiction, cues previously associated with drug use can produce craving and
frequently trigger the resumption of drug taking in individuals vulnerable to relapse …

Increased glutamatergic neurotransmission appears to mediate the reinforcing properties of
drugs of abuse, including ethanol (EtOH). We have shown that administration of ceftriaxone …

Downregulation of the astroglial glutamate transporter GLT-1 is observed in the nucleus
accumbens (NAc) following administration of multiple drugs of abuse. The decrease in GLT …

Receiving a neurodegenerative disease (NDD) diagnosis, such as Alzheimer's disease,
Parkinson's disease, Huntington's disease, or amyotrophic lateral sclerosis, is devastating …

Chronic ethanol consumption is known to downregulate expression of the major glutamate
transporter 1 (GLT-1), which increases extracellular glutamate concentrations in subregions …

The fronto-striatal circuitry, involving the nucleus accumbens, ventral tegmental area, and
prefrontal cortex, mediates goal-directed behavior and is targeted by both drugs of abuse …

Glutamatergic system has an important role in cocaine-seeking behavior. Studies have
reported that chronic exposure to cocaine induces downregulation of glutamate transporter …

Using the extinction-reinstatement model of cocaine relapse, we and others have
demonstrated that the antibiotic ceftriaxone attenuates cue-and cocaine-primed …