Objective To evaluate the effectiveness of ceftriaxone treatment in attenuating relapse-like
ethanol drinking behavior in male P rats following 14-weeks of continuous ethanol …

Aim Glutamate has been considered as neurotransmitter that is critical in triggering relapse
to drugs of abuse, including ethanol and cocaine. Extracellular glutamate concentrations are …

Mitochondrial dysfunction has been implicated in the degeneration of dopamine (DA)
neurons in Parkinson's disease (PD). In addition, animal models of PD utilizing neurotoxins …

The number of people who suffer from a substance abuse disorder has continued to rise
over the last decade; particularly, the number of drug-related overdose deaths has sharply …

Cocaine addiction is a global public health and socioeconomic issue that requires
pharmacological and cognitive therapies. Currently there are no FDA-approved medications …

Cocaine use disorder currently lacks Food and Drug Administration–approved treatments. In
rodents, the glutamate transporter-1 (GLT-1) is downregulated in the nucleus accumbens …

Ceftriaxone is an antibiotic that increases central nervous system (CNS) protein expression
of the glutamate transporters GLT-1 and xCT and ameliorates pathological behaviors in …

Rationale Extinction of drug seeking is facilitated by NMDA receptor (NMDAr) agonists, but it
remains unclear whether extinction is dependent on NMDAr activity. Objectives We …

Glutamate transporters (EAAT) have been implicated in the drug addiction behavior. We
determined whether EAAT type 3 (EAAT3) played a role in morphine addiction. Six-to eight …

Dopamine and glutamate play critical roles in the reinforcing effects of cocaine. We
demonstrated that a single intraperitoneal administration of cocaine induces a significant …