Cancer is one of the most common causes of death. So, its lethal effect increases with time.
Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or …

In response to environmental stimuli, cells make a series of adaptive changes to combat the
injury, repair the damage, and increase the tolerance to the stress. However, once the …

Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial
heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA …

Neurodegenerative diseases are usually sporadic in nature and commonly influenced by a
wide range of genetic, life style and environmental factors. A unifying feature of Alzheimer's …

In the past 15 years, the proteasome has been validated as an anti-cancer drug target and
20S proteasome inhibitors (such as bortezomib and carfilzomib) have been approved by the …

The E3 ubiquitin ligase UBE3A, also known as E6-AP, has a multitude of ascribed functions
and targets relevant to human health and disease. Epigenetic regulation of the UBE3A gene …

Introduction The therapeutic targeting of the ubiquitin-proteasome pathway (UPP) through
inhibitors of the 20S proteasome core proteolytic activities has revolutionized the treatment …

Abstract Derivation of induced Pluripotent Stem Cells (iPSCs) by reprogramming somatic
cells to a pluripotent state has revolutionized stem cell research. Ensuing this, various …

Evolutionarily conserved DDB1‐and CUL4‐associated factor 13 (DCAF13) is a recently
discovered substrate receptor for the cullin RING‐finger ubiquitin ligase 4 (CRL4) E3 …

The extracellular matrix (ECM) is a network of structural proteins, glycoproteins and
proteoglycans that assists independent cells in aggregating and forming highly organized …