[HTML][HTML] From animal poisons and venoms to medicines: achievements, challenges and perspectives in drug discovery

KCF Bordon, CT Cologna, EC Fornari-Baldo… - Frontiers in …, 2020 - frontiersin.org
Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

[HTML][HTML] COVID-19 and antiphospholipid antibodies: time for a reality check?

EJ Favaloro, BM Henry, G Lippi - Seminars in Thrombosis and …, 2022 - thieme-connect.com
Antiphospholipid antibodies (aPL) comprise a panel of autoantibodies that reflect a potential
prothrombotic risk in several autoimmune conditions, most notably antiphospholipid …

How to optimize activated partial thromboplastin time (APTT) testing: solutions to establishing and verifying normal reference intervals and assessing APTT reagents …

EJ Favaloro, G Kershaw… - … in thrombosis and …, 2019 - thieme-connect.com
The activated partial thromboplastin time (APTT) assay is a very common coagulation test,
used for several reasons. The test is conventionally used for assessing the contact factor …

Antiphospholipid antibodies in COVID-19-associated pneumonia patients in intensive care unit

S Karahan, K Erol, RC Yuksel, C Artan… - Modern …, 2022 - academic.oup.com
Abstract Objectives Antiphospholipid antibodies (APAs) increase the risk of excessive blood
clotting, but their role in COVID‐19 remains unclear. We aimed to investigate the presence …

[HTML][HTML] Molecular mechanisms of “antiphospholipid antibodies” and their paradoxical role in the pathogenesis of “seronegative APS”

R Misasi, A Longo, S Recalchi, D Caissutti… - International Journal of …, 2020 - mdpi.com
Antiphospholipid Syndrome (APS) is an autoimmune disease characterized by arterial
and/or venous thrombosis and/or pregnancy morbidity, associated with circulating …

Cell-bound complement activation products in SLE

R Ramsey-Goldman, J Li, T Dervieux… - Lupus science & …, 2017 - lupus.bmj.com
Diagnosis of SLE is based on clinical manifestations and laboratory findings. Timely
diagnosis and treatment are important to control disease activity and prevent organ damage …

Genetic testing for thrombophilia-related genes: observations of testing patterns for factor V Leiden (G1691A) and prothrombin gene “Mutation”(G20210A)

EJ Favaloro - Seminars in thrombosis and hemostasis, 2019 - thieme-connect.com
Thrombophilia is a generic term that defines an increased propensity toward thrombosis and
associated morbidity. Factor V Leiden (FVL; G1691A) and the prothrombin gene mutation …

[HTML][HTML] Bioactive molecules derived from snake venoms with therapeutic potential for the treatment of thrombo-cardiovascular disorders associated with COVID-19

F Chérifi, F Laraba-Djebari - The protein journal, 2021 - Springer
As expected, several new variants of Severe Acute Respiratory Syndrome-CoronaVirus-2
(SARS-CoV-2) emerged and have been detected around the world throughout this …

Antiphospholipid syndrome: Diagnosis and management in the obstetric patient

E Arslan, DW Branch - Best practice & research Clinical obstetrics & …, 2020 - Elsevier
Antiphospholipid syndrome (APS) is a rare condition clinically characterized by thrombotic
events or pregnancy complications and confirmed by one or more repeatedly positive …

[HTML][HTML] “New” antigenic targets and methodological approaches for refining laboratory diagnosis of antiphospholipid syndrome

R Misasi, A Capozzi, A Longo, S Recalchi… - Journal of immunology …, 2015 - hindawi.com
Antiphospholipid antibodies (aPLs) are a heterogeneous group of antibodies directed
against phospholipids or protein/phospholipid complexes. Currently, aPLs are assessed …