Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …

The tobacco-specific N-nitrosamines 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone
(NNK) and N′-nitrosonornicotine (NNN) always occur together and exclusively in tobacco …

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …

DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …

The measurement of DNA adducts, the covalent modifications of DNA upon the exposure to
the environmental and dietary genotoxicants and endogenously produced electrophiles …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a potent lung carcinogen present in
tobacco products, and exposure to it is likely one of the factors contributing to the …

The exposure of human DNA to genotoxic compounds induces the formation of covalent
DNA adducts, which may contribute to the initiation of carcinogenesis. Liquid …

Long-term exposures to environmental toxicants are causative factors for human health
effects. DNA damages are of great interest in that they can serve as the potential biomarkers …

The International Agency for Research on Cancer has classified the tobacco-specific
nitrosamines N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are carcinogenic in animal models and …