Among the numerous agents that damage DNA, tobacco products remain one of the most
lethal and result in the most diverse set of DNA lesions. This perspective aims to provide an …

Tobacco-specific nitrosamines are the most abundant strong carcinogens in smokeless
tobacco products. This chapter focuses on three of the most important of these compounds …

In spite of the overwhelming epidemiological evidence for cigarette smoke (CS)
carcinogenicity, less attention has been paid to the effects of CS as a complex mixture. As …

Humans are frequently exposed to low levels of hazardous chemicals in the environment,
diet, and professional occupation, which damage the genome. DNA damage can also occur …

Upon entry into a host, carcinogens are subjected to a variety of Phase I and Phase II
metabolic pathways that result in bioactivation or detoxification. The bioactivation pathways …

Rationale As a new approach to DNA adductomics, we directly reacted intact, double‐
stranded (ds)‐DNA under warm conditions with an alkylating mass tag followed by analysis …

Formation of DNA adducts is a key event for a genotoxic mode of action, and their presence
is often used as a surrogate for mutation and increased cancer risk. Interest in DNA adducts …

DNA alkylation damage is caused by numerous sources in the environment. Alkylation
damage can stall standard DNA polymerases and replication instead occurs through a …