Tissue-resident fibroblasts are mesenchymal cells which possess an impressive plasticity in
their ability to modify their properties according to the requirements of the microenvironment …

Coronary heart disease (CHD) is closely related to oxidative stress and inflammatory
response and is the most common cardiovascular disease (CVD). Iron is an essential …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Cardiac fibrosis (CF) is considered an ultimate common pathway of a wide variety of heart
diseases in response to diverse pathological and pathophysiological stimuli. Mitochondria …

Pathological cardiac hypertrophy is a key risk factor for the development of heart failure and
predisposes individuals to cardiac arrhythmia and sudden death. While physiological …

Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity
develop long-term fibrotic processes in the heart, promoting pathological cardiac …

Diabetic foot is one of the most common complications of diabetes, requiring repeated
surgical interventions and leading to amputation. In the absence of effective drugs, new …

The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

The adult mammalian heart has limited endogenous regenerative capacity and heals
through the activation of inflammatory and fibrogenic cascades that ultimately result in the …

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …