[HTML][HTML] Orthostatic hypotension in older people: considerations, diagnosis and management

M Dani, A Dirksen, P Taraborrelli, D Panagopolous… - Clinical Medicine, 2021 - Elsevier
Orthostatic hypotension (OH) is very common in older people and is encountered daily in
emergency departments and medical admissions units. It is associated with a higher risk of …

24-hour levodopa-carbidopa intestinal gel: clinical experience and practical recommendations

S Thakkar, VSC Fung, A Merola, M Rollins, MJ Soileau… - CNS drugs, 2021 - Springer
Infusion of levodopa-carbidopa intestinal gel (LCIG; also designated carbidopa-levodopa
enteral suspension) for 16 hours is a standard treatment for patients with advanced …

Cerebral small vessel disease may worsen motor function, cognition, and mood in Parkinson's disease

H Chen, H Wan, M Zhang, G Liu, X Wang… - Parkinsonism & Related …, 2021 - Elsevier
Introduction Emerging evidence has suggested that cerebral small vessel disease (CSVD)
may worsen motor function and cognition in Parkinson's disease (PD). However, the effect of …

Identifying Parkinson's disease subtypes with motor and non-motor symptoms via model-based multi-partition clustering

F Rodriguez-Sanchez, C Rodriguez-Blazquez… - Scientific Reports, 2021 - nature.com
Identification of Parkinson's disease subtypes may help understand underlying disease
mechanisms and provide personalized management. Although clustering methods have …

A pilot to assess target engagement of terazosin in Parkinson's disease

JL Schultz, AN Brinker, J Xu, SE Ernst, F Tayyari… - Parkinsonism & related …, 2022 - Elsevier
Background Impaired brain energy metabolism is a key feature of Parkinson's disease (PD).
Terazosin (TZ) binds phosphoglycerate kinase 1 and stimulates its activity, which enhances …

Validation of blood pressure measurement using a smartwatch in patients with Parkinson's disease

JH Ahn, J Song, I Choi, J Youn, JW Cho - Frontiers in neurology, 2021 - frontiersin.org
Objectives: We aimed to validate the accuracy of blood pressure (BP) measurement using a
smartwatch in patients with Parkinson's disease (PD). Materials and Methods: We compared …

Early autonomic and cognitive dysfunction in PD, DLB and MSA: blurring the boundaries between α-synucleinopathies

G Palermo, E Del Prete, U Bonuccelli, R Ceravolo - Journal of Neurology, 2020 - Springer
Differential diagnosis between Parkinson's disease, dementia with Lewy bodies and
multiple system atrophy can be difficult, especially because in early phase they might …

Orthostatic hypotension is associated with cognitive decline in Parkinson disease

K Longardner, E Bayram, I Litvan - Frontiers in neurology, 2020 - frontiersin.org
Introduction: Cognitive impairment and orthostatic hypotension (OH) are common, disabling
Parkinson disease (PD) symptoms that are strongly correlated. Whether the relationship is …

Impaired dynamic cerebral autoregulation: A potential mechanism of orthostatic hypotension and dementia in Parkinson's disease

H Chen, E Xu, F Zhou, Q Li, J Zeng, S Mei… - Frontiers in Aging …, 2022 - frontiersin.org
Background Orthostatic hypotension (OH) and cognitive impairment are common non-motor
symptoms of Parkinson's disease (PD). This study aimed to investigate whether impaired …

Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies

R Tanaka, N Hattori - Hypertension Research, 2022 - nature.com
Circadian blood pressure (BP) rhythm is important for the maintenance of healthy daily life,
and its disruption is associated with poor outcomes. Cardiovascular autonomic failure is …