Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

[HTML][HTML] Bone remodeling: an operational process ensuring survival and bone mechanical competence

S Bolamperti, I Villa, A Rubinacci - Bone Research, 2022 - nature.com
Bone remodeling replaces old and damaged bone with new bone through a sequence of
cellular events occurring on the same surface without any change in bone shape. It was …

Exosomes

DM Pegtel, SJ Gould - Annual review of biochemistry, 2019 - annualreviews.org
Exosomes are small, single-membrane, secreted organelles of∼ 30 to∼ 200 nm in
diameter that have the same topology as the cell and are enriched in selected proteins …

Bone‐Targeted Exosomes: Strategies and Applications

J Wang, X Li, S Wang, J Cui, X Ren… - Advanced Healthcare …, 2023 - Wiley Online Library
As the global population ages, bone‐related diseases have increasingly become a major
social problem threatening human health. Exosomes, as natural cell products, have been …

[HTML][HTML] Exosome-derived microRNAs of human milk and their effects on infant health and development

BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

[HTML][HTML] Co–culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches

G Borciani, G Montalbano, N Baldini, G Cerqueni… - Acta biomaterialia, 2020 - Elsevier
Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

Engineered extracellular vesicles for bone therapy

Y Jiang, J Li, X Xue, Z Yin, K Xu, J Su - Nano Today, 2022 - Elsevier
Extracellular vesicles, which are secreted by living cells and play a critical role in cellular
communication, have emerged as a promising cell-free strategy in the treatment of many …

[HTML][HTML] In vitro Models of Bone Remodelling and Associated Disorders

R Owen, GC Reilly - Frontiers in bioengineering and biotechnology, 2018 - frontiersin.org
Disruption of bone remodelling by diseases such as osteoporosis results in an imbalance
between bone formation by osteoblasts and resorption by osteoclasts. Research into these …

[HTML][HTML] Human oral stem cells, biomaterials and extracellular vesicles: a promising tool in bone tissue repair

O Trubiani, GD Marconi, SD Pierdomenico… - International Journal of …, 2019 - mdpi.com
Tissue engineering and/or regenerative medicine are fields of life science exploiting both
engineering and biological fundamentals to originate new tissues and organs and to induce …

microRNA-935-modified bone marrow mesenchymal stem cells-derived exosomes enhance osteoblast proliferation and differentiation in osteoporotic rats

Y Zhang, X Cao, P Li, Y Fan, L Zhang, X Ma, R Sun… - Life sciences, 2021 - Elsevier
Aims The involvement of several microRNAs (miRNAs) in osteogenic differentiation has
been indicated recently. Also, exosomes, derived from different cells, could shuttle specific …