[HTML][HTML] Digital twins for multiple sclerosis
I Voigt, H Inojosa, A Dillenseger, R Haase… - Frontiers in …, 2021 - frontiersin.org
An individualized innovative disease management is of great importance for people with
multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional …
multiple sclerosis (pwMS) to cope with the complexity of this chronic, multidimensional …
The role of TH17 cells in multiple sclerosis: Therapeutic implications
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …
NRF2 as a therapeutic target in neurodegenerative diseases
MS Brandes, NE Gray - ASN neuro, 2020 - journals.sagepub.com
Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …
the pathogenesis of numerous neurodegenerative conditions including among others …
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages
W He, A Henne, M Lauterbach, E Geißmar… - Nature …, 2022 - nature.com
Since its discovery in inflammatory macrophages, itaconate has attracted much attention
due to its antimicrobial and immunomodulatory activity,–. However, instead of investigating …
due to its antimicrobial and immunomodulatory activity,–. However, instead of investigating …
Clinical outcome measures in multiple sclerosis: a review
H Inojosa, D Schriefer, T Ziemssen - Autoimmunity reviews, 2020 - Elsevier
A proper clinical evaluation of patients with Multiple Sclerosis (MS) is of great importance to
detect MS progression. It provides important data for physicians on their daily practice as …
detect MS progression. It provides important data for physicians on their daily practice as …
[HTML][HTML] Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications
AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
[HTML][HTML] Antioxidant and anti-inflammatory effect of Nrf2 inducer dimethyl fumarate in neurodegenerative diseases
SA Scuderi, A Ardizzone, I Paterniti, E Esposito… - Antioxidants, 2020 - mdpi.com
Neurodegenerative diseases (NDs) represents debilitating conditions characterized by
degeneration of neuronal cells in specific brain areas, causing disability and death in …
degeneration of neuronal cells in specific brain areas, causing disability and death in …
The role of natural products in revealing NRF2 function
Covering: up to 2020 The transcription factor NRF2 is one of the body's major defense
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
mechanisms, driving transcription of> 300 antioxidant response element (ARE)-regulated …
[HTML][HTML] Beetroot, a remarkable vegetable: Its nitrate and phytochemical contents can be adjusted in novel formulations to benefit health and support cardiovascular …
D dos S. Baião, DVT da Silva, VMF Paschoalin - Antioxidants, 2020 - mdpi.com
The cardioprotective effects of dietary nitrate from beetroot in healthy and hypertensive
individuals are undeniable and irrefutable. Nitrate and nitrate-derived nitrite are precursors …
individuals are undeniable and irrefutable. Nitrate and nitrate-derived nitrite are precursors …
Targeting NRF2 to treat cancer
NRF2 is a basic leucine zipper (bZip) transcription factor that is the master regulator of redox
homeostasis. Under basal conditions, the cellular level of NRF2 is low due to a …
homeostasis. Under basal conditions, the cellular level of NRF2 is low due to a …