PCSK9-directed therapies: an update
JL Katzmann, U Laufs - Current Opinion in Lipidology, 2024 - journals.lww.com
Long-term inhibition of PCSK9 with monoclonal antibodies is safe and conveys sustained
cardiovascular benefit. Novel strategies to inhibit PCSK9 function such as orally available …
cardiovascular benefit. Novel strategies to inhibit PCSK9 function such as orally available …
Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies
HC Medina-Munoz, E Kofman, P Jagannatha… - Nature …, 2024 - nature.com
RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function.
Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding …
Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding …
[PDF][PDF] Deconstructing cancer with precision genome editing
GA Johnson, SI Gould… - Biochemical Society …, 2024 - portlandpress.com
Recent advances in genome editing technologies are allowing investigators to engineer and
study cancer-associated mutations in their endogenous genetic contexts with high precision …
study cancer-associated mutations in their endogenous genetic contexts with high precision …
Systems metabolic engineering of Escherichia coli for high-yield production of Para-hydroxybenzoic acid
Q Liu, X Chen, G Hu, R Chu, J Liu, X Li, C Gao, L Liu… - Food Chemistry, 2024 - Elsevier
Para-hydroxybenzoic acid (PHBA) is extensively used as an additive in the food and
cosmetics industries, significantly enhancing product shelf life and stability. While microbial …
cosmetics industries, significantly enhancing product shelf life and stability. While microbial …
Design and Engineering of Light‐Induced Base Editors Facilitating Genome Editing with Enhanced Fidelity
Y Sun, Q Chen, Y Cheng, X Wang, Z Deng… - Advanced …, 2024 - Wiley Online Library
Base editors, which enable targeted locus nucleotide conversion in genomic DNA without
double‐stranded breaks, have been engineered as powerful tools for biotechnological and …
double‐stranded breaks, have been engineered as powerful tools for biotechnological and …
Exploiting protein domain modularity to enable synthetic control of engineered cells
Y Haikal, J Blazeck - Current Opinion in Biomedical Engineering, 2024 - Elsevier
The ability to precisely control cellular function in response to external stimuli can enhance
the function and safety of cell therapies. In this review, we will detail how the modularity of …
the function and safety of cell therapies. In this review, we will detail how the modularity of …
Split Proteins and Reassembly Modules for Biological Applications
J Bae, J Kim, J Choi, H Lee, M Koh - ChemBioChem, 2024 - Wiley Online Library
Split systems, modular entities enabling controlled biological processes, have become
instrumental in biological research. This review highlights their utility across applications like …
instrumental in biological research. This review highlights their utility across applications like …