Introduction. Colchicine is used mainly for the treatment and prevention of gout and for
familial Mediterranean fever (FMF). It has a narrow therapeutic index, with no clear-cut …

Gout is a clinical syndrome resulting from the deposition of urate (monosodium urate
monohydrate) crystals. The crystals may be deposited in a joint, leading to an acute …

OBJECTIVE:: To present an update of the use of colchicine in patients with familial
Mediterranean fever (FMF) and other rheumatic and nonrheumatic diseases. DATA …

The daily application of colchicine is the standard therapy for prophylaxis of attacks and
amyloid deposition in familial Mediterranean fever. However, because of many issues (eg …

Gout is a condition characterized by the deposition of monosodium urate crystals in the
joints or soft tissue. The four phases of gout include asymptomatic hyperuricemia, acute …

Over the last decade, evidence has demonstrated that long-term, low-dose colchicine (0.5
mg daily) is effective for preventing gout flare and cardiovascular (CV) events in a wide …

Pharmacological and Clinical Basis of Treatment of Familial Mediterranean Fever (FMF) with
Colchicine or Analogues: An Update Page 1 Current Drug Targets - Inflammation & Allergy …

There are three stages in the management of gout:(i) treating the acute attack;(ii) lowering
excess stores of uric acid to prevent flares of gouty arthritis and to prevent tissue deposition …

New light has been shed on the mechanisms of action of colchicine in crystal-associated
arthropathies. Colchicine, long used to treat gout, arrests microtubule assembly and inhibits …

Colchicine is a unique anti-inflammatory drug with respect to its limited clinical usefulness
and its mode of action. Colchicine is mainly indicated for the treatment and prophylaxis of …