Immunomodulatory biomaterials for tissue repair
R Whitaker, B Hernaez-Estrada… - Chemical …, 2021 - ACS Publications
All implanted biomaterials are targets of the host's immune system. While the host
inflammatory response was once considered a detrimental force to be blunted or avoided, in …
inflammatory response was once considered a detrimental force to be blunted or avoided, in …
[HTML][HTML] Polymeric particle-based therapies for acute inflammatory diseases
ER Brannon, MV Guevara, NJ Pacifici, JK Lee… - Nature Reviews …, 2022 - nature.com
Acute inflammation is essential for initiating and coordinating the body's response to injuries
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …
and infections. However, in acute inflammatory diseases, inflammation is not resolved but …
Therapeutic induction of antigen-specific immune tolerance
JE Kenison, NA Stevens, FJ Quintana - Nature Reviews Immunology, 2024 - nature.com
The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …
antigen-specific immune tolerance remains an important unmet clinical need for the …
[HTML][HTML] Nanotherapies for sepsis by regulating inflammatory signals and reactive oxygen and nitrogen species: New insight for treating COVID-19
L Chen, Q Huang, T Zhao, L Sui, S Wang, Z Xiao… - Redox biology, 2021 - Elsevier
SARS-CoV-2 has caused up to 127 million cases of COVID-19. Approximately 5% of COVID-
19 patients develop severe illness, and approximately 40% of those with severe illness …
19 patients develop severe illness, and approximately 40% of those with severe illness …
[HTML][HTML] Cell membrane-based biomimetic nanoparticles and the immune system: immunomodulatory interactions to therapeutic applications
M Sushnitha, M Evangelopoulos, E Tasciotti… - … in bioengineering and …, 2020 - frontiersin.org
Nanoparticle-based drug delivery systems have been synthesized from a wide array of
materials. The therapeutic success of these platforms hinges upon their ability to favorably …
materials. The therapeutic success of these platforms hinges upon their ability to favorably …
Neutrophils preferentially phagocytose elongated particles—An opportunity for selective targeting in acute inflammatory diseases
Polymeric particles have recently been used to modulate the behavior of immune cells in the
treatment of various inflammatory conditions. However, there is little understanding of how …
treatment of various inflammatory conditions. However, there is little understanding of how …
[HTML][HTML] Nanocarriers for effective delivery: modulation of innate immunity for the management of infections and the associated complications
Innate immunity is the first line of defense against invading pathogens. Innate immune cells
can recognize invading pathogens through recognizing pathogen-associated molecular …
can recognize invading pathogens through recognizing pathogen-associated molecular …
[HTML][HTML] From co-infections to autoimmune disease via hyperactivated innate immunity: COVID-19 autoimmune coagulopathies, autoimmune myocarditis and …
R Root-Bernstein - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophilia and the production of neutrophil extracellular traps (NETs) are two of many
measures of increased inflammation in severe COVID-19 that also accompany its …
measures of increased inflammation in severe COVID-19 that also accompany its …
[HTML][HTML] Immunomodulatory nanoparticles mitigate macrophage inflammation via inhibition of PAMP interactions and lactate-mediated functional reprogramming of NF …
JJM Lasola, AL Cottingham, BL Scotland, N Truong… - Pharmaceutics, 2021 - mdpi.com
Inflammation is a key homeostatic process involved in the body's response to a multitude of
disease states including infection, autoimmune disorders, cancer, and other chronic …
disease states including infection, autoimmune disorders, cancer, and other chronic …
[HTML][HTML] Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management
C Song, J Xu, C Gao, W Zhang, X Fang… - Frontiers in …, 2022 - frontiersin.org
Sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to
infection. Macrophages play significant roles in host against pathogens and the …
infection. Macrophages play significant roles in host against pathogens and the …