Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte
count is a marker of inflammation that is widely available in clinical practice. This paper …

Atherosclerosis is a chronic immune-inflammatory disease in which the interactions of
monocytes with activated endothelium are crucial events leading to atherosclerotic alteration …

Obesity has been suggested to be a low-grade systemic inflammatory state, therefore we
studied the interaction between human adipocytes and monocytes via adipose tissue (AT) …

Aims The inflammatory responses of monocytes/macrophages and the stimulation of lipid
uptake into these cells by oxidized low density lipoprotein (oxLDL) are critical to the initiation …

Macrophages are essential innate immune cells and form our first line of immune defense.
Also known as professional phagocytes, macrophages interact and take up various …

Background Leukocyte adhesion to the vascular endothelium and subsequent
transendothelial migration play essential roles in the pathogenesis of cardiovascular …

Foam cell formation from macrophages with subsequent fatty streak formation plays a key
role in early atherogenesis. Foam cell formation is thought to be induced by Low Density …

Objective—Atherosclerotic lesions contain hypoxic areas, but the pathophysiological
importance of hypoxia is unknown. Hypoxia-inducible factor-1α (HIF-1α) is a key …

Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess
lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a …

Objective—Cells of adaptive immunity have been implicated in atherogenesis. Though
substantial information is available on immune cells in atherosclerotic lesions of the lamina …