Candida albicans at Host Barrier Sites: Pattern Recognition Receptors and Beyond

M Swidergall - Pathogens, 2019 - mdpi.com
Over the last decades, fungal infections have emerged as a growing threat to human health.
Although the human body is at potential risk, various body sites host several commensal …

Secreted Aspartic Protease Cleavage of Candida albicans Msb2 Activates Cek1 MAPK Signaling Affecting Biofilm Formation and Oropharyngeal Candidiasis

S Puri, R Kumar, S Chadha, S Tati, HR Conti, B Hube… - PloS one, 2012 - journals.plos.org
Perception of external stimuli and generation of an appropriate response are crucial for host
colonization by pathogens. In pathogenic fungi, mitogen activated protein kinase (MAPK) …

Mucin glycans: A target for cancer therapy

L Sun, Y Zhang, W Li, J Zhang, Y Zhang - Molecules, 2023 - mdpi.com
Mucin glycans are an important component of the mucus barrier and a vital defence against
physical and chemical damage as well as pathogens. There are 20 mucins in the human …

A genome-wide screen of deletion mutants in the filamentous Saccharomyces cerevisiae background identifies ergosterol as a direct trigger of macrophage pyroptosis

K Koselny, N Mutlu, AY Minard, A Kumar, DJ Krysan… - MBio, 2018 - Am Soc Microbiol
Phagocytic cells such as macrophages play an important role in the host defense
mechanisms mounted in response to the common human fungal pathogen Candida …

Nutrient and stress sensing in pathogenic yeasts

JC Rutherford, YS Bahn, B Van Den Berg… - Frontiers in …, 2019 - frontiersin.org
More than 1.5 million fungal species are estimated to live in vastly different environmental
niches. Despite each unique host environment, fungal cells sense certain fundamentally …

Flor yeast: new perspectives beyond wine aging

JL Legras, J Moreno-Garcia, S Zara, G Zara… - Frontiers in …, 2016 - frontiersin.org
The most important dogma in white-wine production is the preservation of the wine aroma
and the limitation of the oxidative action of oxygen. In contrast, the aging of Sherry and …

Profiling the secretome and extracellular proteome of the potato late blight pathogen Phytophthora infestans

HJG Meijer, FM Mancuso, G Espadas, MF Seidl… - Molecular & Cellular …, 2014 - ASBMB
Oomycetes are filamentous organisms that cause notorious diseases, several of which have
a high economic impact. Well known is Phytophthora infestans, the causal agent of potato …

Beyond the wall: Candida albicans secret(e)s to survive

AG Sorgo, CJ Heilmann, S Brul… - FEMS microbiology …, 2013 - academic.oup.com
The opportunistic fungal pathogen Candida albicans occupies various niches of the human
body such as the skin and the mucosal surfaces of the gastrointestinal and urogenital tracts …

An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses

IAI Hampe, J Friedman, M Edgerton… - PLoS …, 2017 - journals.plos.org
The opportunistic fungal pathogen Candida albicans frequently produces genetically altered
variants to adapt to environmental changes and new host niches in the course of its life-long …

Fungal resilience and host–pathogen interactions: future perspectives and opportunities

AJP Brown - Parasite Immunology, 2023 - Wiley Online Library
We are constantly exposed to the threat of fungal infection. The outcome—clearance,
commensalism or infection—depends largely on the ability of our innate immune defences …