Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell
junctions that are crucial for the maintenance of vessel integrity and proper lymphatic …

The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …

Rationale: Cardiac lymphangiogenesis contributes to the reparative process post-
myocardial infarction, but the factors and mechanisms regulating it are not well understood …

Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

The potential existence and roles of the meningeal lymphatic system in normal and
pathological brain function have been a long-standing enigma. Recent evidence suggests …

The formation and remodeling of a functional circulatory system is critical for sustaining
prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells …

Rationale: Mutations in GJC2 and GJA1, encoding Cxs (connexins) 47 and 43, respectively,
are linked to lymphedema, but the underlying mechanisms are unknown. Because efficient …

Prolonged pressure overload triggers cardiac hypertrophy and frequently leads to heart
failure (HF). Vascular endothelial growth factor‐C (VEGF‐C) and its receptor VEGFR‐3 are …

Lymphedema is a complex disease caused by the accumulation of fluid in the tissues
resulting from a dysfunctional or damaged lymphatic vasculature. In developed countries …

Lymphatic vasculature is an integral part of the cardiovascular system where it maintains
interstitial fluid balance. Additionally, lymphatic vasculature regulates lipid assimilation and …