[HTML][HTML] Pathophysiology and treatment strategies of acute myopathy and muscle wasting after sepsis

RT Mankowski, O Laitano, TL Clanton… - Journal of Clinical …, 2021 - mdpi.com
Sepsis survivors experience a persistent myopathy characterized by skeletal muscle
weakness, atrophy, and an inability to repair/regenerate damaged or dysfunctional …

[HTML][HTML] Musculoskeletal complications following critical illness: A scoping review

OD Gustafson, MA Williams, S McKechnie… - Journal of Critical …, 2021 - Elsevier
Purpose To explore the extent to which musculoskeletal (MSK) complications have been
reported following critical illness, identifying evidence gaps and providing recommendations …

[HTML][HTML] Differential contractile response of critically ill patients to neuromuscular electrical stimulation

JJ Grunow, M Goll, NM Carbon, ME Liebl… - Critical Care, 2019 - Springer
Background Neuromuscular electrical stimulation (NMES) has been investigated as a
preventative measure for intensive care unit-acquired weakness. Trial results remain …

[HTML][HTML] Transcriptomic analysis reveals abnormal muscle repair and remodeling in survivors of critical illness with sustained weakness

CJ Walsh, J Batt, MS Herridge, S Mathur, GD Bader… - Scientific reports, 2016 - nature.com
ICU acquired weakness (ICUAW) is a common complication of critical illness characterized
by structural and functional impairment of skeletal muscle. The resulting physical impairment …

[HTML][HTML] Hidden agenda-the involvement of endoplasmic reticulum stress and unfolded protein response in inflammation-induced muscle wasting

M Kny, J Fielitz - Frontiers in Immunology, 2022 - frontiersin.org
Critically ill patients at the intensive care unit (ICU) often develop a generalized weakness,
called ICU-acquired weakness (ICUAW). A major contributor to ICUAW is muscle atrophy, a …

Can the critically ill patient generate sufficient energy to facilitate exercise in the ICU?

DE Bear, SM Parry, ZA Puthucheary - Current Opinion in Clinical …, 2018 - journals.lww.com
Can the critically ill patient generate sufficient energy to... : Current Opinion in Clinical Nutrition
& Metabolic Care Can the critically ill patient generate sufficient energy to facilitate exercise in …

[HTML][HTML] Construct and criterion validity of muscle ultrasonography for assessment of skeletal muscle in patients recovering from COVID-19

KP Mayer, K Kosmac, Y Wen, SM Parry, S Dhar… - Frontiers in …, 2023 - frontiersin.org
Background: The purpose was to investigate the content, construct, and criterion validity of
muscle ultrasound in a mixed cohort of participants recovering from mild and critical COVID …

[HTML][HTML] Models of disuse muscle atrophy: therapeutic implications in critically ill patients

E Barreiro - Annals of translational medicine, 2018 - ncbi.nlm.nih.gov
Skeletal muscle weakness is common in the intensive care units (ICU). Approximately 50%
of patients under mechanical ventilation for more than 7 days show signs of ICU-acquired …

[HTML][HTML] Altered cholesterol homeostasis in critical illness-induced muscle weakness: effect of exogenous 3-hydroxybutyrate

C Goossens, R Weckx, S Derde, S Vander Perre… - Critical Care, 2021 - Springer
Background Muscle weakness is a complication of critical illness which hampers recovery.
In critically ill mice, supplementation with the ketone body 3-hydroxybutyrate has been …

Urinary titin is a novel biomarker for muscle atrophy in nonsurgical critically ill patients: a two-center, prospective observational study

N Nakanishi, R Tsutsumi, K Hara… - Critical Care …, 2020 - journals.lww.com
Objectives: Although skeletal muscle atrophy is common in critically ill patients, biomarkers
associated with muscle atrophy have not been identified reliably. Titin is a spring-like protein …