An update on current treatment strategies for managing bronchiolitis obliterans syndrome after lung transplantation
A Arjuna, MT Olson, R Walia, RM Bremner… - Expert review of …, 2021 - Taylor & Francis
Introduction Bronchiolitis obliterans syndrome (BOS), a subtype of chronic lung allograft
dysfunction, is quite common, with up to half of all lung recipients developing BOS within 5 …
dysfunction, is quite common, with up to half of all lung recipients developing BOS within 5 …
Nlrp3 inflammasome inhibitor MCC950 ameliorates obliterative bronchiolitis by inhibiting Th1/Th17 response and promoting treg response after orthotopic tracheal …
KY Xu, S Tong, CY Wu, XC Ding, JL Chen… - …, 2020 - journals.lww.com
Background. Obliterative bronchiolitis (OB) remains the major complication limiting long-
term survival of patients after lung transplantation. We aimed to explore the effects of the …
term survival of patients after lung transplantation. We aimed to explore the effects of the …
[HTML][HTML] HDAC6-specific inhibitor suppresses Th17 cell function via the HIF-1α pathway in acute lung allograft rejection in mice
W Zhou, J Yang, G Saren, H Zhao, K Cao, S Fu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Background: Previous animal experiments and clinical studies indicated the critical role of
Th17 cells in lung transplant rejection. Therefore, the downregulation of Th17 cell function in …
Th17 cells in lung transplant rejection. Therefore, the downregulation of Th17 cell function in …
[HTML][HTML] Taurodeoxycholic acid and valine reverse obesity-associated augmented alloimmune responses and prolong allograft survival
M Quante, J Iske, H Uehara, K Minami, Y Nian… - American Journal of …, 2022 - Elsevier
Obesity initiates a chronic inflammatory network linked to perioperative complications and
increased acute rejection rates in organ transplantation. Bariatric surgery is the most …
increased acute rejection rates in organ transplantation. Bariatric surgery is the most …
Therapeutic reconditioning of damaged lungs by transient heat stress during ex-vivo lung perfusion
A Ojanguren, R Parapanov, A Debonneville… - American Journal of …, 2023 - Elsevier
Ex-vivo lung perfusion (EVLP) may serve as a platform for the pharmacological repair of
lung grafts before transplantation (LTx). We hypothesized that EVLP could also permit non …
lung grafts before transplantation (LTx). We hypothesized that EVLP could also permit non …
Azithromycin partially mitigates dysregulated repair of lung allograft small airway epithelium
Background. Dysregulated airway epithelial repair following injury is a proposed mechanism
driving posttransplant bronchiolitis obliterans (BO), and its clinical correlate bronchiolitis …
driving posttransplant bronchiolitis obliterans (BO), and its clinical correlate bronchiolitis …
[PDF][PDF] Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device
C Figueiredo, D Eicke, Y Yuzefovych, M Avsar… - Scientific reports, 2019 - Springer
Low haemocompatibility of left ventricular assist devices (LVAD) surfaces necessitates
anticoagulative therapy. Endothelial cell (EC) seeding can support haemocompatibility …
anticoagulative therapy. Endothelial cell (EC) seeding can support haemocompatibility …
[HTML][HTML] IL-17A contributes to lung fibrosis in a model of chronic pulmonary graft-versus-host disease
T Martinu, WC McManigle, FL Kelly, ME Nelson… - …, 2019 - ncbi.nlm.nih.gov
Background: Chronic pulmonary graft-versus-host disease (cpGVHD) after hematopoietic
cell transplant (HCT) manifests as progressive airway and parenchymal lung fibrosis. Based …
cell transplant (HCT) manifests as progressive airway and parenchymal lung fibrosis. Based …
SOCS3 overexpression in T cells ameliorates chronic airway obstruction in a murine heterotopic tracheal transplantation model
K Mesaki, M Yamane, S Sugimoto, M Fujisawa… - Surgery today, 2019 - Springer
Purpose Suppressor of cytokine signaling-3 (SOCS3) is a negative feedback inhibitor of
cytokine signaling with T-cell-mediated immunosuppressive effects on obliterative …
cytokine signaling with T-cell-mediated immunosuppressive effects on obliterative …
Recipient bone marrow-derived IL-17 receptor A-positive cells drive allograft fibrosis in a mouse intrapulmonary tracheal transplantation model
T Watanabe, SC Juvet, K Boonstra, Z Guan, B Joe… - Transplant …, 2021 - Elsevier
IL-17A is implicated in the pathogenesis of chronic lung allograft dysfunction, which limits
survival after lung transplantation. While many cells express the IL-17 receptor A (IL-17RA) …
survival after lung transplantation. While many cells express the IL-17 receptor A (IL-17RA) …