Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function
below the injury site and is associated with a poor prognosis. The inhibitory environment that …

Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …

Increasing studies focus on chondroitin sulfate (CS) degradation to improve its biological
activity. The review mainly introduces the degradation methods of CS and their mechanisms …

Brain and spinal cord injury can result in permanent cognitive, motor, sensory and
autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for …

Oral preparations of chondroitin sulfate (CS) have long been used as anti-osteoarthritis (anti-
OA) drugs. However, little is known about the degradation of CS by human gut microbiota. In …

The variation in the sulfation profile of chondroitin sulfate (CS)/dermatan sulfate (DS) chains
regulates central nervous system development in vertebrates. Notably, the disulfated …

The glycosaminoglycan of decorin, dermatan sulfate (DS), has been suggested to contribute
to the mechanical properties of soft connective tissues such as ligaments and tendons. This …

GalAGs (galactosaminoglycans) are one subset of the GAG (glycosaminoglycan) family of
chemically heterogeneous polysaccharides that are involved in a wide range of biological …

Chondroitinase B from Pedobacter heparinus is the only known enzyme strictly specific for
dermatan sulfate and is a widely used enzymatic tool for the structural characterization of …

Glycomics represents one of the last frontiers and most challenging in omic analysis.
Glycosylation occurs in the endoplasmic reticulum and the Golgi organelle and its control is …