Flavonoids: structure–function and mechanisms of action and opportunities for drug development
Flavonoids are polyphenolic phytochemicals produced in fruits, nuts and vegetables and
dietary consumption of these structurally diverse compounds is associated with multiple …
dietary consumption of these structurally diverse compounds is associated with multiple …
Neuroinflammation as a therapeutic target in retinitis pigmentosa and quercetin as its potential modulator
JT Ortega, B Jastrzebska - Pharmaceutics, 2021 - mdpi.com
The retina is a multilayer neuronal tissue located in the back of the eye that transduces the
environmental light into a neural impulse. Many eye diseases caused by endogenous or …
environmental light into a neural impulse. Many eye diseases caused by endogenous or …
Molecular mechanisms underlying inherited photoreceptor degeneration as targets for therapeutic intervention
A Bighinati, E Adani, A Stanzani… - Frontiers in Cellular …, 2024 - frontiersin.org
Retinitis pigmentosa (RP) is a form of retinal degeneration characterized by primary
degeneration of rod photoreceptors followed by a secondary cone loss that leads to vision …
degeneration of rod photoreceptors followed by a secondary cone loss that leads to vision …
Photic generation of 11-cis-retinal in bovine retinal pigment epithelium
Photoisomerization of the 11-cis-retinal chromophore of rod and cone visual pigments to an
all-trans-configuration is the initiating event for vision in vertebrates. The regeneration of 11 …
all-trans-configuration is the initiating event for vision in vertebrates. The regeneration of 11 …
Protective effects of flavonoids in acute models of light-induced retinal degeneration
Degeneration of photoreceptors caused by excessive illumination, inherited mutations, or
aging is the principal pathology of blinding diseases. Pharmacological compounds that …
aging is the principal pathology of blinding diseases. Pharmacological compounds that …
Flavonoids improve the stability and function of P23H rhodopsin slowing down the progression of retinitis pigmentosa in mice
The balanced homeostasis of the G protein–coupled receptor (GPCR), rhodopsin (Rho), is
required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to …
required for vision. Misfolding mutations in Rho cause photoreceptor death, leading to …
Ebola and Marburg virus VP35 coiled-coil validated as antiviral target by tripartite split-GFP complementation
L Zinzula, AM Mereu, M Orsini, C Seeleitner, A Bracher… - Iscience, 2022 - cell.com
Ebola virus (EBOV) and Marburg virus (MARV) are highly pathogenic viruses in humans,
against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil …
against which approved antivirals are lacking. During EBOV and MARV infection, coiled-coil …
Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal
FJ Roushar, AG McKee, CP Kuntz, JT Ortega… - Journal of Biological …, 2022 - ASBMB
Over 100 mutations in the rhodopsin gene have been linked to a spectrum of retinopathies
that include retinitis pigmentosa and congenital stationary night blindness. Though most of …
that include retinitis pigmentosa and congenital stationary night blindness. Though most of …
Polyphenols and visual health: potential effects on degenerative retinal diseases
P Fernandez-Gonzalez, A Mas-Sanchez, P Garriga - Molecules, 2021 - mdpi.com
Dietary polyphenols are a group of natural compounds that have been proposed to have
beneficial effects on human health. They were first known for their antioxidant properties, but …
beneficial effects on human health. They were first known for their antioxidant properties, but …
Nutraceutical molecules slow down retinal degeneration, in Tvrm4 mice a model of retinitis pigmentosa, by genetic modulation of anti-oxidant pathway
Rhodopsin (RHO) mutations are responsible for 25–40% of the dominant cases of retinitis
pigmentosa (RP) with different severity and progression rates. The Tvrm4 mice …
pigmentosa (RP) with different severity and progression rates. The Tvrm4 mice …