Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …

Brains are highly metabolically active organs, consuming 20% of a person's energy at
resting state. A decline in glucose metabolism is a common feature across a number of …

Type 2 diabetes (T2D), a prevalent metabolic disorder lacking effective treatments, is
associated with lysosomal acidification dysfunction, as well as autophagic and mitochondrial …

Neuronal necroptosis–an emerging form of regulated cell death associated with
neuroinflammatory signaling: Alzheimer's disease (AD) is characterized by the presence of …

Synucleinopathies are a group of neurodegenerative disorders characterized by pathologic
aggregates of neural and glial α-synuclein (α-syn) in the form of Lewy bodies (LBs), Lewy …

The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …

Mutations in LRRK2 (encoding leucine‐rich repeat kinase 2 protein, LRRK2) are the most
common genetic risk factors for Parkinson's disease (PD), and increased LRRK2 kinase …

Data mining involves the computational analysis of a plethora of publicly available datasets
to generate new hypotheses that can be further validated by experiments for the improved …

Aims/hypothesis Repeated exposures to insulin-induced hypoglycaemia in people with
diabetes progressively impairs the counterregulatory response (CRR) that restores …