The health effects of vitamin D supplementation: evidence from human studies

R Bouillon, D Manousaki, C Rosen… - Nature Reviews …, 2022 - nature.com
Vitamin D supplementation can prevent and cure nutritional rickets in infants and children.
Preclinical and observational data suggest that the vitamin D endocrine system has a wide …

Guidelines for preventing and treating vitamin D deficiency: a 2023 update in Poland

P Płudowski, B Kos-Kudła, M Walczak, A Fal… - Nutrients, 2023 - mdpi.com
Introduction: All epidemiological studies suggest that vitamin D deficiency is prevalent
among the Polish general population. Since vitamin D deficiency was shown to be among …

[HTML][HTML] The clinician's guide to prevention and treatment of osteoporosis

MS LeBoff, SL Greenspan, KL Insogna… - Osteoporosis …, 2022 - Springer
Osteoporosis is the most common metabolic bone disease in the USA and the world. It is a
subclinical condition until complicated by fracture (s). These fractures place an enormous …

Supplemental vitamin D and incident fractures in midlife and older adults

MS LeBoff, SH Chou, KA Ratliff, NR Cook… - … England Journal of …, 2022 - Mass Medical Soc
Background Vitamin D supplements are widely recommended for bone health in the general
population, but data on whether they prevent fractures have been inconsistent. Methods In …

Vitamin D sources, metabolism, and deficiency: available compounds and guidelines for its treatment

LJ Dominguez, M Farruggia, N Veronese… - Metabolites, 2021 - mdpi.com
Studies on vitamin/hormone D deficiency have received a vast amount of attention in recent
years, particularly concerning recommendations, guidelines, and treatments. Moreover …

Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue …

P Lips, KD Cashman, C Lamberg-Allardt… - European journal of …, 2019 - academic.oup.com
Vitamin D deficiency (serum 25-hydroxyvitamin D (25 (OH) D)< 50 nmol/L or 20 ng/mL) is
common in Europe and the Middle East. It occurs in< 20% of the population in Northern …

Vitamin D and calcium for the prevention of fracture: a systematic review and meta-analysis

P Yao, D Bennett, M Mafham, X Lin, Z Chen… - JAMA network …, 2019 - jamanetwork.com
Importance Vitamin D and calcium supplements are recommended for the prevention of
fracture, but previous randomized clinical trials (RCTs) have reported conflicting results, with …

Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis

MJ Bolland, A Grey, A Avenell - The lancet Diabetes & …, 2018 - thelancet.com
Background The effects of vitamin D on fractures, falls, and bone mineral density are
uncertain, particularly for high vitamin D doses. We aimed to determine the effect of vitamin …

Effect of high-dose vitamin D supplementation on volumetric bone density and bone strength: a randomized clinical trial

LA Burt, EO Billington, MS Rose, DA Raymond… - Jama, 2019 - jamanetwork.com
Importance Few studies have assessed the effects of daily vitamin D doses at or above the
tolerable upper intake level for 12 months or greater, yet 3% of US adults report vitamin D …