Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Alzheimer's disease (AD), certainly the most widespread proteinopathy, has as classical
neuropathological hallmarks, two groups of protein aggregates: senile plaques and …

Background Increased total tau (t-tau) in cerebrospinal fluid (CSF) is a key characteristic of
Alzheimer's disease (AD) and is considered to result from neurodegeneration. T-tau levels …

Tau aggregation is a defining histopathological feature of Alzheimer's disease and other
tauopathies. However, the cellular mechanisms involved in tau propagation remain unclear …

Importance Factors associated with synapse loss beyond amyloid-β plaques and
neurofibrillary tangles may more closely correlate with the emergence of cognitive deficits in …

Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial
temporal lobe. However, there is evidence that, independently of Aβ, age-related tau …

Alzheimer's disease (AD), the most common cause of dementia, is a complex and
multifactorial disease involving genetic and environmental factors, with …

Neuronal death is one of the most common pathological hallmarks of diverse neurological
diseases, which manifest varying degrees of cognitive or motor dysfunction. Neuronal death …

Sodium-glucose cotransporter-2 inhibitors (SGLT2is), such as empagliflozin, lower blood
glucose in type 2 diabetes mellitus and improve cardiorenal outcomes regardless of …

The synapse has consistently been considered a vulnerable and critical target within
Alzheimer's disease, and synapse loss is, to date, one of the main biological correlates of …