Emerging diagnostics and therapeutics for Alzheimer disease
WK Self, DM Holtzman - Nature medicine, 2023 - nature.com
Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …
strategies that slow or prevent its clinical progression have largely remained elusive, until …
[HTML][HTML] Brain macrophage development, diversity and dysregulation in health and disease
Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …
Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models
J Rueda‐Carrasco, D Sokolova, SE Lee… - The EMBO …, 2023 - embopress.org
Neuronal hyperactivity is a key feature of early stages of Alzheimer's disease (AD). Genetic
studies in AD support that microglia act as potential cellular drivers of disease risk, but the …
studies in AD support that microglia act as potential cellular drivers of disease risk, but the …
Microglia regulation of central nervous system myelin health and regeneration
SA Kent, VE Miron - Nature Reviews Immunology, 2024 - nature.com
Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …
its development, homeostasis and response to damage and infection. Although microglia …
Immune Activation in Alzheimer Disease
Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …
efficient curative treatment available, its medical, social, and economic burdens are …
[HTML][HTML] Microglia maintain structural integrity during fetal brain morphogenesis
AR Lawrence, A Canzi, C Bridlance, N Olivié… - Cell, 2024 - cell.com
Summary Microglia (MG), the brain-resident macrophages, play major roles in health and
disease via a diversity of cellular states. While embryonic MG display a large heterogeneity …
disease via a diversity of cellular states. While embryonic MG display a large heterogeneity …
Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
Y Lan, X Zhang, S Liu, C Guo, Y Jin, H Li, L Wang… - Immunity, 2024 - cell.com
Microglial reactivity to injury and disease is emerging as a heterogeneous, dynamic, and
crucial determinant in neurological disorders. However, the plasticity and fate of disease …
crucial determinant in neurological disorders. However, the plasticity and fate of disease …
[HTML][HTML] Current views on meningeal lymphatics and immunity in aging and Alzheimer's disease
S Rego, G Sanchez, S Da Mesquita - Molecular neurodegeneration, 2023 - Springer
Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …
Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health
Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …
Brain perivascular macrophages: current understanding and future prospects
W Wen, J Cheng, Y Tang - Brain, 2024 - academic.oup.com
Brain perivascular macrophages are specialized populations of macrophages that reside in
the space around cerebral vessels, such as penetrating arteries and venules. With the help …
the space around cerebral vessels, such as penetrating arteries and venules. With the help …