Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: A review
P Xie, HT Luo, WJ Pei, MY Xiao, FF Li, YL Gu… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance Gynostemma pentaphyllum (Thunb.) Makino (G.
pentaphyllum) can be used for both medicinal and tea and has lipid-lowering properties …
pentaphyllum) can be used for both medicinal and tea and has lipid-lowering properties …
Advances in the Bioactivities of Phytochemical Saponins in the Prevention and Treatment of Atherosclerosis
H Luo, J Chen, C Su, L Zha - Nutrients, 2022 - mdpi.com
Atherosclerosis (AS) is a chronic inflammatory disease characterized by hardening and
narrowing of arteries. AS leads to a number of arteriosclerotic vascular diseases including …
narrowing of arteries. AS leads to a number of arteriosclerotic vascular diseases including …
Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1
MY Xiao, FF Li, P Xie, YS Qi, JB Xie, WJ Pei… - Chemico-Biological …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high
morbidity and mortality. Targeting abnormal cholesterol metabolism is a potential …
morbidity and mortality. Targeting abnormal cholesterol metabolism is a potential …
Liver lipidomics analysis reveals the anti-obesity and lipid-lowering effects of gypnosides from heat-processed Gynostemma pentaphyllum in high-fat diet fed mice
P Xie, JB Xie, MY Xiao, M Guo, YS Qi, FF Li, XL Piao - Phytomedicine, 2023 - Elsevier
Abstract Background In traditional Chinese medicine, Gynostemma pentaphyllum (G.
pentaphyllum) is widely used to treat conditions associated with hyperlipidemia, and its …
pentaphyllum) is widely used to treat conditions associated with hyperlipidemia, and its …
[HTML][HTML] Hypolipidemic effect and gut microbiota regulation of Gypenoside aglycones in rats fed a high-fat diet
Abstract Ethnopharmacological relevance Gynostemma pentaphyllum (Thunb.) Makino has
traditional applications in Chinese medicine to treat lipid abnormalities. Gypenosides (GPs) …
traditional applications in Chinese medicine to treat lipid abnormalities. Gypenosides (GPs) …
Protective effect of heat-processed Gynostemma pentaphyllum on high fat diet-induced glucose metabolic disorders mice
JB Xie, P Xie, M Guo, FF Li, MY Xiao, YS Qi… - Frontiers in …, 2023 - frontiersin.org
Glucose metabolic disorders (GMD) can promote insulin resistance (IR) and diabetes, and
damage liver and kidney. Gynostemma pentaphyllum is commonly used in the clinical …
damage liver and kidney. Gynostemma pentaphyllum is commonly used in the clinical …
Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease
X Meng, Y Zhang, Z Li, G Ma, X Zhang… - Phytotherapy …, 2023 - Wiley Online Library
We have previously reported that Gypenoside LXXV (GP‐75), a novel natural PPARγ
agonist isolated from Gynostemma pentaphyllum, ameliorated cognitive deficits in db/db …
agonist isolated from Gynostemma pentaphyllum, ameliorated cognitive deficits in db/db …
Heat stroke-induced cerebral cortex nerve injury by mitochondrial dysfunction: A comprehensive multi-omics profiling analysis
W Fang, B Yin, Z Fang, M Tian, L Ke, X Ma… - Science of the total …, 2024 - Elsevier
In recent years, global warming has led to frequent instances of extremely high temperatures
during summer, arousing significant concern about the adverse effects of high temperature …
during summer, arousing significant concern about the adverse effects of high temperature …
Saponins as therapeutic candidates for atherosclerosis
N Lv, L Wang, M Zeng, Y Wang, B Yu… - Phytotherapy …, 2024 - Wiley Online Library
Drug development for atherosclerosis, the underlying pathological state of ischemic
cardiovascular diseases, has posed a longstanding challenge. Saponins, classified as …
cardiovascular diseases, has posed a longstanding challenge. Saponins, classified as …
Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males
This research aimed to determine the effects of Gynostemma pentaphyllum (G.
pentaphyllum) on exercise performance, AMP-activated protein kinase (AMPK), and …
pentaphyllum) on exercise performance, AMP-activated protein kinase (AMPK), and …