The T cell infiltrates that are formed in human cancers are a modifier of natural disease
progression and also determine the probability of clinical response to cancer …

Traditional cancer treatments use nonspecific drugs and monoclonal antibodies to target
tumor cells. Chimeric antigen receptor (CAR)-T cell therapy, however, leverages the immune …

Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …

Single-cell omics studies provide unique information regarding cellular heterogeneity at
various levels of the molecular biology central dogma. This knowledge facilitates a deeper …

The human immune system is comprised of a diverse and interactive network of specialized
cells localized in diverse tissues throughout the body, where they mediate protection against …

Asthma is a common condition caused by immune and respiratory dysfunction, and it is often
linked to allergy. A systems perspective may prove helpful in unravelling the complexity of …

Breast cancer prognosis is challenging due to the heterogeneity of the disease. Various
computational methods using bulk RNA-seq data have been proposed for breast cancer …

Single-cell mass cytometry, also known as cytometry by time of flight (CyTOF) is a powerful
high-throughput technology that allows analysis of up to 50 protein markers per cell for the …

Mammalian cells display a broad spectrum of phenotypes, morphologies, and functional
niches within biological systems. Our understanding of mechanisms at the individual cellular …

Humoral immunity provides protection from pathogenic infection and is mediated by
antibodies following the differentiation of naive B cells (nBs) to antibody‐secreting cells …