Proteasomal degradation of ubiquitylated proteins is tightly regulated at multiple levels,–. A
primary regulatory checkpoint is the removal of ubiquitin chains from substrates by the …

The COVID-19 pandemic has been a public health emergency with continuously evolving
deadly variants around the globe. Among many preventive and therapeutic strategies, the …

The ring-like ATPase complexes in the AAA+ family perform diverse cellular functions that
require coordination between the conformational transitions of their individual ATPase …

Calmodulin (CaM) is a key signaling protein that triggers several cellular and physiological
processes inside the cell. Upon binding with calcium ion, CaM undergoes large scale …

The AAA+ ATPase complex on proteasome powers its functions through a series of intricate
conformational transitions. Here, we describe a procedure to simulate the conformational …

Proteasomal degradation of ubiquitylated proteins is sophisticatedly regulated at multiple
levels–. A primary regulatory checkpoint is the removal of ubiquitin chains from substrates by …

The ring-shaped hexameric AAA+ ATPase motors are the mechanochemical engines
powering all ATP-dependent proteolytic machines broadly involved in diverse cellular …

The 26S proteasome, an ATP-dependent protease, is the main powerhouse for protein
degradation in all eukaryotic cells. Proteostasis is maintained by the ubiquitin-proteasome …

The 26S proteasome is the largest and most complicated chambered protease known. It is
responsible for regulated degradation of proteins within all eukaryotic cells, and is essential …